Graduate Theses and Dissertations - Microbiology & Immunology
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Vaccine-Induced Antibody and Cellular Correlates and Anti-Correlates of Risk of SIV/HIV Acquisition
(Georgetown University, 2022)RV144 is the only phase III HIV vaccine clinical trial that has demonstrated a statistically significant reduced risk of HIV acquisition (31.2%). In this study, the primary correlate of reduced risk was IgG targeting the ... -
IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ... -
Investigating the Initiation Site of Hepatitis Delta Virus Genome Synthesis
(Georgetown University, 2022)Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three ... -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Robustly Generated from Healthy Donor Blood
(Georgetown University, 2020)Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ...
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