Browsing Graduate Theses and Dissertations - Microbiology & Immunology by Title
Now showing items 1-20 of 34
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Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets
(Georgetown University, 2011)A steady increase in the incidence of fungal infections has been observed over the past few decades, and treatment remains challenging especially for immuno-compromised populations. Identification of the ideal therapeutic ... -
Analysis of hepatitis delta virus RNA structure : effects on RNA-protein interactions and viral replication
(Georgetown University, 2008) -
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ... -
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ... -
Characterization of GII Norovirus VPg Nucleotidylylation and Nucleoside Triphosphate Binding
(Georgetown University, 2016)Human Norovirus (hNoV) is a single-stranded positive-sense RNA virus of Caliciviridae family. It is the major cause of gastroenteritis outbreaks in the United States. The VPg protein of hNoV is a multi-functional protein ... -
Development of a Novel Transfection System to Study Regulation of Hepatitis Delta Virus RNAs by Hepatitis Delta Antigen
(Georgetown University, 2019)Hepatitis delta virus (HDV) is a unique pathogen that co-infects with hepatitis B virus and increase the severity of acute and chronic liver disease. HDV is a negative stranded RNA virus and produces three processed RNAs ... -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Endothelial responses to anthrax lethal toxin and pathogenic implications
(Georgetown University, 2010) -
Examining the Role of STATs and STAT Signaling the Induction, Enhancement, and Prolonged Duration of Antiviral Activity by IFN-γ and IFN-α2a in Combination with Ribavirin
(Georgetown University, 2014)Interferons (IFNs) were discovered in 1957, yet there are still questions as to how IFNs elicit their antiviral, antiproliferative, and immunomodulatory activities. In addition, IFN-α is part of the standard treatment ... -
Function of PHR1 in Candida albicans cell wall assembly
(Georgetown University, 2011) -
Hijacking the Candida albicans Multidrug Resistant Transporter MDR1 to Potentiate Antifungal Activity
(Georgetown University, 2013)Fungal invasive infections of humans are now called "hidden killers". The rising costs of treatment are associated with inappropriate therapy, defined as delayed intervention, inadequate dosage, or administration of an ... -
Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication
(Georgetown University, 2011)Using the Massively Parallel Genetic Algorithm for RNA folding, we show that the core region of the 3'-untranslated region of the dengue virus (DENV) RNA can form two dumbbell structures (5' and 3'DBs) of unequal frequencies ... -
IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ... -
Immune Responses During Resolution of Acute Hepatitis B in Woodchucks and Their Modulation for Treatment of Chronic Hepatitis B
(Georgetown University, 2020)Understanding the innate and adaptive immune responses during resolution of hepatitis B virus (HBV) infection is important for exploring new treatment options for chronic hepatitis B (CHB). Studying acute hepatitis B (AHB) ... -
Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design
(Georgetown University, 2012)Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ... -
Intranasal Vaccination with Murine Cytomegalovirus Expressing Respiratory Syncytial Virus Antigens Promotes Tissue-resident Memory CD8+ T cells
(Georgetown University, 2015)Cytomegalovirus (CMV) vectors are a promising vaccine strategy aimed at eliciting effector CD8+ T cells. CMV-based vaccines have been shown to mediate protection against viral pathogens including simian immunodeficiency ... -
Investigating the Initiation Site of Hepatitis Delta Virus Genome Synthesis
(Georgetown University, 2022)Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three ... -
MECHANISMS CONTROLLING HUMAN NOROVIRUS POLYPROTEIN PROCESSING
(Georgetown University, 2015)Noroviruses (NoV) are the prevailing cause of nonbacterial acute gastroenteritis worldwide and pose a significant financial burden on healthcare systems. The human NoV ORF1 encodes a 200 kDa polyprotein which is cleaved ... -
MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype
(Georgetown University, 2012)Drug resistance remains a major obstacle to the successful treatment of cancer. Cancer cells acquire a pleiotropic resistance phenotype to cisplatin (CisPt), conferring cross-resistance to other xenobiotics. This pleiotropic ...
