• PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program 

  Brown-Clay, Joshua Don (Georgetown University, 2016)

  A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries ...

• α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES 

  Credle, Joel Joseph (Georgetown University, 2015)

  Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...

• EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS 

  Day, Timothy Francis (Georgetown University, 2015)

  Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...

• DESIGN AND SYNTHESIS OF SMALL MOLECULE DISRUPTORS OF EWS-FLI1 IN EWING'S SARCOMA 

  Tosso, Perrer (Georgetown University, 2014)

  Ewing's sarcoma (ES) consists of highly malignant tumors of the bone and soft tissues. Ninety-five percent of ES cases contain a balanced t(11;22)(q24;q12) translocation, combining the amino-terminus of EWS to the ...

• ID3 INDUCES AN ELK-1- AND CASPASE-8-DEPENDENT APOPTOTIC PATHWAY IN SQUAMOUS CARCINOMA CELLS 

  Chen, You-shin (Georgetown University, 2014)

  Inhibitors of differentiation/DNA binding (Id) proteins are helix-loop-helix (HLH) transcription factors. The Id protein family (Id1-Id4) mediates tissue homeostasis by regulating cellular processes including differentiation, ...

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