Graduate Theses and Dissertations - Biochemistry and Molecular & Cellular Biology
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RARRES1 Modulation of Tubulin Deglutamylation Regulates Metabolism and Cell Survival
(Georgetown University, 2018)One of the driving mechanisms of cancer progression is the reprogramming of metabolic pathways in intermediary metabolism. Cancers increase their energy expenditure by increasing ATP production for utilization in anabolic ... -
The Application of Conditional Reprogramming to Drug Discovery and Regenerative Medicine
(Georgetown University, 2018)The Conditional Reprogramming (CR) method has been shown to induce an in vitro stem-like state allowing for the continuous growth of patient-derived epithelial cells. Due to this new culture system, it has been possible ... -
The Role of T Cells in the Hypertension of the Female Dahl Salt-Sensitive Rat
(Georgetown University, 2018)Hypertension (HT) is a major risk factor for cardiovascular diseases (CVD) and affects 1 billion men and women globally. The underlying cause of HT in women is far less studied than in men. Hence it is critically important ... -
MECHANISMS OF OBESITY-RELATED HEPATOCARCINOGENSIS
(Georgetown University, 2017)Nearly a third of the US population is currently obese. The recent rise in liver cancer prevalence correlates with the obesity epidemic and non-alcoholic fatty liver disease (NAFLD). The underlying mechanisms behind the ... -
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
(Georgetown University, 2016)A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries ...
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