Graduate Theses and Dissertations - Biochemistry and Molecular & Cellular Biology
Browse by
Most Recent Submissions
-
Associations between Polymorphisms in Genes in the Nitrite Synthesis Pathway and Mammographic Breast Density, a Biomarker of Breast
(Georgetown University, 2021)The nitrite synthesis pathway may play a role in breast cancer by activating the estrogen receptor alpha (ERα) through an interaction with the ligand-binding domain of the receptor in the absence of estradiol. ERα plays a ... -
The Exploration of Non-Invasive Biomarkers for Lupus Nephritis
(Georgetown University, 2021)Background -
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ... -
Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (CICS) Derived from Germline Pluripotent Stem Cells (HGPSCS) to Combat Myocardial Fibrosis
(Georgetown University, 2021)Stem cell research for treating or curing myocardial fibrosis has culminated in identifying which scenario is more important; 1) stem cell differentiation into cardiomyocytes that integrate electrically with the heart, 2) ... -
Role of the Mitochondrial Citrate Transporter, SLC25A1, in Cancer, Obesity and Liver Steatosis
(Georgetown University, 2021)Alterations in metabolism lead to disruption of normal tissue homeostasis and are hallmarks of many human diseases, including cancer, diabetes and obesity. This work focuses on the mitochondrial transporter Slc25a1, which ...