Browsing Graduate Theses and Dissertations - Biochemistry and Molecular & Cellular Biology by Creation Date
Now showing items 1-20 of 69
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9-cis-retinoic acided mediated endothelial transdifferentiation in breast cancer cells
(Georgetown University, 2008) -
Regulation of cadherin-11 by GSK3 inhibition and TGFbeta1 treatment in cancer cells
(Georgetown University, 2008) -
Expression profiling during ocular development identifies two nlz genes with a critical role in fissure closure
(Georgetown University, 2008) -
Pten-induced kinase 1 (PINK1) and its role in mitochondrial function and dynamics
(Georgetown University, 2008) -
Regulation of telomerase by genistein in human prostate cancer cells
(Georgetown University, 2008) -
Role of Calcium in Activation of Estrogen Receptor-Alpha
(Georgetown University, 2008)ABSTRACT Growth factors are thought to activate estrogen receptor-alpha ERα by phosphorylating the serines in the N-terminus of the receptor. However, this mechanism does not account for the conformational changes that ... -
Id2 re-expression results in the downregulation of p27KIP1 and tumorigenesis in dermal fibroblasts
(Georgetown University, 2009) -
Role of protein-protein interactions in protein import, cholesterol transport and steroid biosynthesis
(Georgetown University, 2010) -
BRCA1 localization to the telomere and its loss upon DNA damage
(Georgetown University, 2010) -
Laminin-1 mediates epigenetic control of the epithelial cadherin for breast cancer cells in three-dimensional culture
(Georgetown University, 2010) -
Prion properties and structural analysis of Candida albicans and Candida glabrata Ure2 proteins
(Georgetown University, 2010)Prions are infectious proteins first implicated as causative agents of scrapie and kuru disease. These diseases are characterized by spongiform brain pathology caused by toxic amyloid filament deposition. Our goal is to ... -
The Contribution of PCPH to Colon Carcinoma
(Georgetown University, 2011)PCPH is a well conserved, single-copy gene whose product is ubiquitously expressed but predominates in kidney, liver, and colon. The protein product belongs to the nucleoside triphosphate diphosphohydrolase family, NTPDase, ... -
Mitochondria-targeted amyloid : relevance to neurotoxicity and Alzheimer's disease
(Georgetown University, 2011) -
In utero exposure to di-(2-ethylhexyl) phthalate reveals the presence of an adrenal-testis axis regulating androgen formation
(Georgetown University, 2011) -
Role of Nag-1 and p75NTR in non-steroidal anti-inflammatory drug inhibition of prostate cancer cell migration
(Georgetown University, 2011) -
The structures, biological activity, and mechanistic studies of novel marine-derived antibacterial compounds
(Georgetown University, 2012)Due to the rise and global proliferation in drug-resistant bacterial infections, we face a continuing need to have a supply of novel antibacterial agents that are not just more potent or useful against a broader spectrum ... -
Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ... -
Activation of estrogen receptor-alpha by nitrite
(Georgetown University, 2012)Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ...
