Browsing Graduate Theses and Dissertations - Biochemistry and Molecular & Cellular Biology by Title
Now showing items 1-20 of 69
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9-cis-retinoic acided mediated endothelial transdifferentiation in breast cancer cells
(Georgetown University, 2008) -
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ... -
Acidic phospholipid deficiency results in an inhibition of chromosomal replication and cell-cycle specific arrest in Escherichia coli
(Georgetown University, 2012)Beyond the simplistic function as an environmental barrier, lipids have a variety of functions. The wealth of knowledge available on Escherichia coli (E. coli), and its small subset of lipid species, makes it an ideal ... -
Activation of estrogen receptor-alpha by nitrite
(Georgetown University, 2012)Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ... -
ALTERATION OF MAMMARY GLAND DEVELOPMENT AND GENE EXPRESSION BY IN UTERO EXPOSURE TO METALLOESTROGENS
(Georgetown University, 2012)Early life exposure to estrogens and estrogen like contaminants in the environment are thought to increase the risk of developing breast cancer due to the early onset of puberty in the exposed female. However, the results ... -
Analysis of Plasmodium falciparum Chloroquine Resistance Transporters in Saccharomyces cerevisiae
(Georgetown University, 2012)The evolution of drug resistance in malaria parasites continues to hamper global eradication campaigns and wreak havoc in endemic countries. Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) ... -
Associations between Polymorphisms in Genes in the Nitrite Synthesis Pathway and Mammographic Breast Density, a Biomarker of Breast
(Georgetown University, 2021)The nitrite synthesis pathway may play a role in breast cancer by activating the estrogen receptor alpha (ERα) through an interaction with the ligand-binding domain of the receptor in the absence of estradiol. ERα plays a ... -
Associations between Polymorphisms in Genes in the Nitrite Synthesis Pathway and Mammographic Breast Density, a Biomarker of Breast
(Georgetown University, 2021)The nitrite synthesis pathway may play a role in breast cancer by activating the estrogen receptor alpha (ERα) through an interaction with the ligand-binding domain of the receptor in the absence of estradiol. ERα plays a ... -
BRCA1 localization to the telomere and its loss upon DNA damage
(Georgetown University, 2010) -
Characterization of Inter-alpha-Trypsin Inhibitor Heavy Chain H4 Glycoprotein Microheterogeneity using Glycopeptide CID Tandem Mass Spectra and Glycan Database Searching
(Georgetown University, 2013)Collision-induced dissociation tandem mass spectrometry (CID MS/MS) is an effective tool for site-specific analysis of glycopeptides and a powerful means of studying glycoprotein microheterogeneity. However, manual ... -
Cis and Trans Regulation of the ANK1 Locus
(Georgetown University, 2012)Many mammalian loci have alternate promoters in which transcripts contain distinct first exons that are fused to a common exon 2 in different cell types. The human ankyrin 1 gene (ANK1) is a classic example of this type ... -
The Contribution of PCPH to Colon Carcinoma
(Georgetown University, 2011)PCPH is a well conserved, single-copy gene whose product is ubiquitously expressed but predominates in kidney, liver, and colon. The protein product belongs to the nucleoside triphosphate diphosphohydrolase family, NTPDase, ... -
Crosstalk between Prokaryotic Replication Initiation and Acidic Phospholipids
(Georgetown University, 2020)The role of cellular membranes in DNA replication has been speculated on for over five decades. Biochemical studies show that Escherichia coli acidic phospholipids influence the chromosomal replication activity of the ... -
THE CX3CR1+ LAMINA PROPRIA DENDRITIC CELL: MASTER SENTINEL OF THE TERMINAL ILEUM
(Georgetown University, 2012)The CX3CR1+ lamina propria dendritic cell (LPDC) of the terminal ileum provides a unique sentinel role, critical for intestinal health. Here, we demonstrate that three Crohn's disease associated single nucleotide polymorphisms ... -
DESIGN AND SYNTHESIS OF SMALL MOLECULE DISRUPTORS OF EWS-FLI1 IN EWING'S SARCOMA
(Georgetown University, 2014)Ewing's sarcoma (ES) consists of highly malignant tumors of the bone and soft tissues. Ninety-five percent of ES cases contain a balanced t(11;22)(q24;q12) translocation, combining the amino-terminus of EWS to the ... -
The Effect of Sequence Variation on the Essential Protein Interactions of Pathogens - a Computational Analysis
(Georgetown University, 2014)ABSTRACT -
EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ... -
"Examining TGF-beta Inhibition, via Smad7, and the Role of The Inhibitors of Differentiation (Id) in Metastatic Melanoma"
(Georgetown University, 2013)TGF-β, Ids and tumorigenesis are interrelated. Smad7 (S7) has been shown to potently suppress melanomagenesis through downregulation of metastasis-related genes such as MMP2, MMP9, osteopontin and CXCR4. Here, we ... -
Expression profiling during ocular development identifies two nlz genes with a critical role in fissure closure
(Georgetown University, 2008) -
Histone ADP-ribosylation by Poly(ADP-ribose) Polymerase 1 (PARP1) Facilitates Inflammatory Gene Transcription by Directly Altering Nucleosome Structure
(Georgetown University, 2012)The packaging of DNA into nucleosomes imposes obstacles to gene transcription as they limit the accessibility of DNA to the transcription machinery. As such, the modulation of nucleosome structure by histone-modifying and ...
