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Validation and Long-Term Follow Up of CRISPR/Cas9 Off-Targets Predicted In Vitro and In Silico Using Error Corrected Sequencing in Rhesus Macaques
(Georgetown University, 2020)
The programmable nuclease technology CRISPR/Cas9 has revolutionized gene editing in the last decade. Due to the risk of off-target editing, accurate and sensitive methods for off-target characterization are crucial prior ...