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α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES
(Georgetown University, 2015)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...
EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)
Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...
Role of protein-protein interactions in protein import, cholesterol transport and steroid biosynthesis
(Georgetown University, 2010)
BRCA1 localization to the telomere and its loss upon DNA damage
(Georgetown University, 2010)
The structures, biological activity, and mechanistic studies of novel marine-derived antibacterial compounds
(Georgetown University, 2012)
Due to the rise and global proliferation in drug-resistant bacterial infections, we face a continuing need to have a supply of novel antibacterial agents that are not just more potent or useful against a broader spectrum ...
Modulation of dopamine transporter trafficking by the synuclein family of proteins
(Georgetown University, 2013)
Dopamine signaling is controlled in part by pre-synaptic re-uptake of dopamine through the dopamine transporter (DAT), and is therefore regulated by the distribution of DAT to the cell surface. DAT trafficking is modulated ...
Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
Laminin-1 mediates epigenetic control of the epithelial cadherin for breast cancer cells in three-dimensional culture
(Georgetown University, 2010)
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
(Georgetown University, 2016)
A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries ...
