Browsing Graduate Theses and Dissertations - Tumor Biology by Title
Now showing items 37-56 of 81
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Matriptase as a Novel Therapeutic Target in Non-Hodgkin Lymphoma
(Georgetown University, 2018)Non-Hodgkin Lymphoma (NHL) is a heterogeneous group of cancers derived from lymphocytes that is increasing in incidence. Advances in genetic diagnostic techniques and the introduction of immunotherapy have allowed significant ... -
Matriptase Is A Reactive Oxygen Species (ROS) Biosensor that Contributes to ER-Negative Breast Cancer Proliferation And Migration
(Georgetown University, 2019)Matriptase is a type-II serine protease that is widely expressed in epithelial tissues and is known to play a role in normal epithelial cell integrity. Matriptase expression and activation are normally tightly regulated ... -
Mechanisms of epithelial cell cancer generation: genetic risk factors on cancer progression investigated using in vivo models and at a single cell level
(Georgetown University, 2012)Loss of Brca1, loss of p53, AIB1/AIB1delta3 over-expression, and ERalpha; over-expression, are risk factors for breast cancer development. These risk factors influence on mammary gland development and breast cancer risk ... -
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ... -
Mechanisms Regulating Growth Progression of Salivary Gland Neoplasms Using Mucoepidermoid Carcenoma Primary Cells
(Georgetown University, 2017)Acquiring patient-derived primary cancer cells is a means towards individualized cancer treatment and a critical step for precision medicine. Strategies that allow efficient isolation of primary cells that enable genetic ... -
The Modulation of Estrogen Induced Apoptosis in Breast Cancer
(Georgetown University, 2014)Development of acquired antihormone resistance exposes a vulnerability in estrogen receptor (ER) positive breast cancer: estrogen induced apoptosis. Estrogen (E2) induces apoptosis in long-term E2-deprived MCF7 cells ... -
Molecular characterization of animal models of pheochromocytoma
(Georgetown University, 2009) -
The Molecular Determinants of Tumor Cell Modulation of Immune Selection
(Georgetown University, 2015)Over the past century, the identification of molecules that tumor cells utilize to manipulate the activation or survival of immune cells has proven difficult. Expression analyses have helped to discover the downregulation ... -
The Molecular Determinants of Tumor Cell Sensitivity and Resistance to Antibody-Dependent Cellular Cytotoxicity (ADCC)
(Georgetown University, 2013)Monoclonal antibodies represent the vanguard of targeted therapy due to their specificity and versatility. Aside from disrupting tumor cell survival and proliferation through cell surface receptor interactions, antibodies ... -
Molecular Features of Human Bone Marrow Stem Cells
(Georgetown University, 2012)Understanding the quality and quantity of resident bone marrow cells as well as circulating bone marrow derived cells (BMDC) are key to unlocking the complexity of their contribution to physiological hemostasis or pathological ... -
Molecular Modulation of Estrogen-Induced Apoptosis in Long-Term Estrogen-Deprived Breast Cancer Cells
(Georgetown University, 2014)Estrogen receptor (ER)-positive breast cancer cell lines have been instrumental in modeling breast cancer and providing an opportunity to document the development and evolution of acquired anti-hormone resistance. Models ... -
A multi-faceted approach to the detection and treatment of pancreatic cancer
(Georgetown University, 2010) -
A multi-faceted approach to the detection and treatment of pancreatic cancer
(Georgetown University, 2010) -
Novel Base Excision Repair and Hypoxanthine in Live Human Cells
(Georgetown University, 2018)Elucidating the mechanism of DNA damage and mutation is key to understating cancer genesis. In the first section of this thesis we examined base excision repair enzymes (BER) responsible for mitigating damage to DNA. BER ... -
Novel Relationships of Splicing Factors and Regulation in TMZ-Resistant Glioblastoma
(Georgetown University, 2019)Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ... -
The Nuclear Function of the Splice Variant Amplified in Breast Cancer 1-Delta4 Contributes to its Oncogenicity
(Georgetown University, 2011)The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant of AIB1 called AIB1-Delta4 that ... -
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ... -
Predicting Disease Course in Bladder Cancer: STAG2 as a Prognostic Biomarker
(Georgetown University, 2019)Bladder cancer is the fifth most common cancer in the United States and the fourth most common in men, with >80,000 new cases annually. While most tumors can be surgically resected, as many as 70% of these tumors will ... -
RARRES1 regulation of alpha-tubulin tyrosination, cytokinesis and vertebrate embryonic development
(Georgetown University, 2009) -
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ...
