Browsing Graduate Theses and Dissertations - Tumor Biology by Title
Now showing items 6-25 of 77
-
CADHERIN-11 MEDIATION OF TUMOR PROGRESSION AND INVASION IN POOR PROGNOSIS CANCERS: A VIABLE THERAPEUTIC TARGET
(Georgetown University, 2009)Loss of E-cadherin is considered a hallmark of epithelial carcinogenesis and has been well-studied to date. Likewise, increases in N-cadherin are known to lead to tumor progression and metastasis in various cancers. A ... -
Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ... -
CDK inhibitor VMY-1-103 causes cell cycle arrest and apoptosis in cancer cell lines
(Georgetown University, 2012)The mammalian cell cycle is a tightly controlled process that -
CIRCUMVENTING ANTIGEN LOSS TO POTENTIATE CANCER IMMUNOTHERAPY
(Georgetown University, 2015)Cancer cells become resistant to monoclonal antibody (mAb) therapy when they lose the cell surface antigens that mAbs target. To circumvent immune escape and maximize the efficacy of mAb therapy, new approaches to mitigate ... -
DAP12 impacts trafficking and surface stability of killer cell immunoglobulin-like receptors on natural killer cells
(Georgetown University, 2012)Killer cell immunoglobulin-like receptors (KIR) aid in the regulation of natural killer (NK) cell activity. In this study, the effect of the interaction between the two domain stimulatory KIR (KIR2DS) and their adapter, ... -
Defining the Factors that Regulate the Conversion to a Trailblazer Epithelial to Mesenchymal Transition State
(Georgetown University, 2021)Tumor heterogeneity resulting from the co-existence of phenotypically diverse tumor cellpopulations is a major contributor in the pathogenesis of several human malignancies. In addition to the steady acquisition of heritable ... -
DEREGULATED ESTROGEN RECEPTOR ALPHA-INITIATED PRENEOPLASIA AND ITS PROGRESSION: ROLE OF STAT5A AND CYCLIN D1
(Georgetown University, 2009)Deregulation of estrogen pathway has been linked to the pathophysiology of breast cancer. CERM (Conditional Estrogen Receptor alpha in Mammary epithelium) mice with deregulated ERalpha (ER) in the mammary epithelium develop ... -
Development of Novel Computational Methodologies for Analyzing Post-Processed Untargeted LC-MS Metabolomics Data
(Georgetown University, 2014)In recent years, the field of metabolomics has quickly risen to become a crucial platform for conducting biological research. Its unique capabilities, which provides unparalleled comprehensive quantitative insight into the ... -
DEVELOPMENT OF NOVEL COMPUTATIONAL METHODS FOR DRUG DISCOVERY AND REPURPOSING IN ONCOLOGIC DISEASES AND OTHER ILLNESSES
(Georgetown University, 2015)Targeting disease-related proteins is important for drug discovery, yet target-based method have not been fruitful. Bottlenecks involve: (1) establishing biologically valid drug- protein target associations, and (2) assessing ... -
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ... -
Drivers of cancer cell invasion and metastasis
(Georgetown University, 2012)Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, extravasation at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and ... -
Effects of CDK4/6 Inhibition on Progression of Early Stage Breast Cancer
(Georgetown University, 2019)Here we demonstrate the efficacy of palbociclib in targeting the cell cycle kinase CDK4/6 and canonical pathways downstream in both normal breast epithelial (MCF10A) and early stage breast cancer cells (MCFDCIS) resulting ... -
Enhancing Anti-Cancer Properties of Human Natural Killer Cells
(Georgetown University, 2021)Immunotherapy has revolutionized cancer treatment. Certain immunotherapies, such as immune checkpoint inhibitors and CAR-T cell therapy, provide long lasting remissions. Unfortunately, the majority of tumors are unresponsive ... -
Epigenetic Modifications: Indicators of Tissue-Specific Damage and Therapeutic Targets in Cancer
(Georgetown University, 2020)Cancer is a disease involving changes in the genome and abnormal, uncontrolled growth of tissue. The hallmarks of cancer include evading apoptosis, insensitivity to anti-growth signals, sustained angiogenesis, limitless ... -
ERRβ Splice Variants Differentially Regulate Cell Cycle Progression
(Georgetown University, 2014)Orphan receptors comprise nearly half of all members of the nuclear receptor superfamily. Despite having broad structural similarities to the classical estrogen receptors, estrogen-related receptors (ERRs) have their own ... -
ETS FAMILY OF TRANSCRIPTION FACTORS AS A THERAPEUTIC TARGET IN CANCER
(Georgetown University, 2016)The ETS family of transcription factors share a conserved DNA binding domain that recognizes a purine rich consensus sequence with GGAA/T motif. ETS genes have been implicated in a wide array of malignancies including acute ... -
EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein
(Georgetown University, 2012)Ewing sarcoma family of tumors (ESFT) consists of highly malignant tumors of the bone and soft tissue. Ninety-five percent of cases contain a balanced t(11;22) or t(21;22) rearrangement, combining the amino-terminus of ... -
Expression Levels of the Nuclear Coactivator AIB1 in Drug Resistance and Tumor Progression of Triple Negative Breast Cancer
(Georgetown University, 2019)Breast cancer is the most diagnosed cancer and the most frequent cause of cancer mortality in women worldwide. Immunoreactive assays as well as gene expression profiling of breast cancer have shown a high degree of ... -
A GENOME-SCALE CRISPR SCREEN TO IDENTIFY ESSENTIAL GENES FOR THE EFFECTOR FUNCTION OF CYTOTOXIC T LYMPHOCYTES
(Georgetown University, 2017)Somatic gene mutations and dysregulations can alter the vulnerability of a cancer cell to T cell based immune selection. To systematically identify genes that positively regulate the sensitivity of cancer cells to T ... -
HEMATOPOIETIC CELL POPULATION SEGREGATION THROUGH FULL-LENGTH TRANSCRIPTOME SEQUENCING
(Georgetown University, 2015)“Progress in science results from new technologies, new discoveries and new ideas, probably in that order.” Nobel Laureate Sydney Brenner (1927 - )
