Browsing Graduate Theses and Dissertations - Tumor Biology by Title
Now showing items 24-43 of 77
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A GENOME-SCALE CRISPR SCREEN TO IDENTIFY ESSENTIAL GENES FOR THE EFFECTOR FUNCTION OF CYTOTOXIC T LYMPHOCYTES
(Georgetown University, 2017)Somatic gene mutations and dysregulations can alter the vulnerability of a cancer cell to T cell based immune selection. To systematically identify genes that positively regulate the sensitivity of cancer cells to T ... -
HEMATOPOIETIC CELL POPULATION SEGREGATION THROUGH FULL-LENGTH TRANSCRIPTOME SEQUENCING
(Georgetown University, 2015)“Progress in science results from new technologies, new discoveries and new ideas, probably in that order.” Nobel Laureate Sydney Brenner (1927 - ) -
The Human Papillomavirus Type 16 E5 Protein: Stress Signaling and Expression in Cervical Cancer Cell Lines
(Georgetown University, 2012)ABSTRACT -
Identification and therapeutic targeting of novel transforming pathways in human glioblastoma multiforme
(Georgetown University, 2010) -
THE IDENTIFICATION OF CELLULAR GENES ALTERED BY HTERT AND HPV-16 IN THE IMMORTALIZATION OF HUMAN KERATINOCYTES
(Georgetown University, 2012)Studies have shown that wild-type hTERT protein can functionally replace the HPV-16E6 protein, which cooperates with the viral E7 protein in the immortalization of primary keratinocytes. Previously, we made the surprising ... -
Identifying Molecular Determinants of Immune Rejection in Pancreatic Cancer
(Georgetown University, 2020)Worldwide, nearly half a million people are diagnosed with pancreatic cancer every year, with mortality rates of more than 90%. Pancreatic cancer has unique biological features. It is characterized by atypical neoplastic ... -
Identifying Molecular Mechanisms of Resistance to Antibody Dependent Cell Mediated Cytotoxicity (ADCC)
(Georgetown University, 2018)Antibody dependent cellular cytotoxicity (ADCC) is one mechanism by which anti-epidermal growth factor receptor (EGFR)-directed monoclonal antibodies (mAb) exert their antitumor effects. While mechanisms of resistance to ... -
IGFBP-3 mediates the effect of tumor suppressor NKX3.1 on prostate cancer cell proliferation
(Georgetown University, 2008) -
In Vivo DNA Repair Mechanisms and Carcinogenesis
(Georgetown University, 2014)The maintenance of the genome is an important barrier to carcinogenesis, and one of the major cellular pathways involved in genome maintenance is DNA repair. There are several types of DNA repair pathways, but one type, ... -
Induction of apoptosis and autophagy by the small molecule inhibitor VMY-1-103 in cancer cell lines and reduction of tumor growth in vivo
(Georgetown University, 2013)Cancer is a class of diseases in which cells divide uncontrollably and are able to spread throughout the body. In particular, cancer of the prostate and brain, specifically medulloblastoma, are particularly deadly because ... -
Integrated Genomic Studies to Discern Tumor Heterogeneity and Prognostic Subgroups in Hepatocellular Carcinoma
(Georgetown University, 2014)Globally, hepatocellular carcinoma (HCC) accounts for 70-85% of primary liver cancers and is the second leading cause of male cancer death. Among patients there is widespread tumor heterogeneity, yet only a single FDA-approved ... -
Matriptase as a Novel Therapeutic Target in Non-Hodgkin Lymphoma
(Georgetown University, 2018)Non-Hodgkin Lymphoma (NHL) is a heterogeneous group of cancers derived from lymphocytes that is increasing in incidence. Advances in genetic diagnostic techniques and the introduction of immunotherapy have allowed significant ... -
Matriptase Is A Reactive Oxygen Species (ROS) Biosensor that Contributes to ER-Negative Breast Cancer Proliferation And Migration
(Georgetown University, 2019)Matriptase is a type-II serine protease that is widely expressed in epithelial tissues and is known to play a role in normal epithelial cell integrity. Matriptase expression and activation are normally tightly regulated ... -
Mechanisms of epithelial cell cancer generation: genetic risk factors on cancer progression investigated using in vivo models and at a single cell level
(Georgetown University, 2012)Loss of Brca1, loss of p53, AIB1/AIB1delta3 over-expression, and ERalpha; over-expression, are risk factors for breast cancer development. These risk factors influence on mammary gland development and breast cancer risk ... -
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ... -
Mechanisms Regulating Growth Progression of Salivary Gland Neoplasms Using Mucoepidermoid Carcenoma Primary Cells
(Georgetown University, 2017)Acquiring patient-derived primary cancer cells is a means towards individualized cancer treatment and a critical step for precision medicine. Strategies that allow efficient isolation of primary cells that enable genetic ... -
The Modulation of Estrogen Induced Apoptosis in Breast Cancer
(Georgetown University, 2014)Development of acquired antihormone resistance exposes a vulnerability in estrogen receptor (ER) positive breast cancer: estrogen induced apoptosis. Estrogen (E2) induces apoptosis in long-term E2-deprived MCF7 cells ... -
Molecular characterization of animal models of pheochromocytoma
(Georgetown University, 2009) -
The Molecular Determinants of Tumor Cell Modulation of Immune Selection
(Georgetown University, 2015)Over the past century, the identification of molecules that tumor cells utilize to manipulate the activation or survival of immune cells has proven difficult. Expression analyses have helped to discover the downregulation ... -
The Molecular Determinants of Tumor Cell Sensitivity and Resistance to Antibody-Dependent Cellular Cytotoxicity (ADCC)
(Georgetown University, 2013)Monoclonal antibodies represent the vanguard of targeted therapy due to their specificity and versatility. Aside from disrupting tumor cell survival and proliferation through cell surface receptor interactions, antibodies ...
