Browsing Graduate Theses and Dissertations - Tumor Biology by Title
Now showing items 48-67 of 77
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Novel Base Excision Repair and Hypoxanthine in Live Human Cells
(Georgetown University, 2018)Elucidating the mechanism of DNA damage and mutation is key to understating cancer genesis. In the first section of this thesis we examined base excision repair enzymes (BER) responsible for mitigating damage to DNA. BER ... -
Novel Relationships of Splicing Factors and Regulation in TMZ-Resistant Glioblastoma
(Georgetown University, 2019)Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ... -
The Nuclear Function of the Splice Variant Amplified in Breast Cancer 1-Delta4 Contributes to its Oncogenicity
(Georgetown University, 2011)The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant of AIB1 called AIB1-Delta4 that ... -
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ... -
Predicting Disease Course in Bladder Cancer: STAG2 as a Prognostic Biomarker
(Georgetown University, 2019)Bladder cancer is the fifth most common cancer in the United States and the fourth most common in men, with >80,000 new cases annually. While most tumors can be surgically resected, as many as 70% of these tumors will ... -
RARRES1 regulation of alpha-tubulin tyrosination, cytokinesis and vertebrate embryonic development
(Georgetown University, 2009) -
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ... -
Regulators of Cancer Cell Vascular Invasion and Malignancy
(Georgetown University, 2018)A metastasizing cancer cell will experience a series of diverse and often lethal selective pressures as it travels from a primary tumor to a distant organ site. Two crucial events in this multistep journey encompass cancer ... -
RELATIONSHIP OF THE METABOLOMIC PROFILING IN BLOOD TO SMOKING BEHAVIOR
(Georgetown University, 2012)Better biomarkers of cancer risk are needed for smokers to enhance early detection and support the FDA as it considers cigarette performance standards and evaluate health claims for modified tobacco products. Metabolomics ... -
RESF1 Is a Metastasis Susceptibility Gene for Estrogen Receptor Negative Breast Cancer
(Georgetown University, 2021)Breast cancer is the most frequently diagnosed and the second most fatal cancer for women in America. Most breast cancer-related mortality is due to metastatic disease. However, despite the importance of metastasis for ... -
The Response of Cancer Cells to Local Changes in Extracellular Stiffness
(Georgetown University, 2017)Durotaxis is a mechanism of directed cell migration in which cells respond to gradients of extracellular stiffness. While durotaxis has been predominantly characterized in a subset of mesenchymal cells, the potential for ... -
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ... -
The role of the chemokine receptor CXCR4 in EGFRvIII-expressing breast cancer
(Georgetown University, 2009) -
Single-cell Biology Uncovers Cell Death as a Potential Driver of Tumor Heterogeneity and Fitness
(Georgetown University, 2021)Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous cancer type with limited treatment options. Identifying drivers of tumor heterogeneity may lead to better therapeutic options and favorable patient ... -
Social Isolation Stress, Obesity, and Breast Cancer Risk in Mice
(Georgetown University, 2014)Social isolation is a potent psychosocial stressor and is associated with obesity and increased breast cancer risk and mortality. In this thesis, I investigated the combined effects of social isolation stress and obesity ... -
Solute Carriers and Heat Shock Proteins Modulate Endocrine Therapy Resistance in Hormone Positive Breast Cancer
(Georgetown University, 2020)Resistance to endocrine therapies remains a major challenge for patients with estrogen receptor-positive (ER+) breast cancer. Adaptive reprogramming of cellular metabolism in response to treatment is one feature of this ... -
Studies of Breast Cancer Chemoprevention in Human High-Risk Primary Cells and Genetically Engineered Mouse Models
(Georgetown University, 2018)BRCA1 mutations have been associated with a 50-80% increased risk of developing breast cancer by the age of 70. Current recommendations for women carrying BRCA1 mutations include risk-reducing surgeries. Chemoprevention ... -
A Systems Approach to Understand the Molecular Synergy of Combined mTOR/Histone Deacetylase (HDAC) Inhibition in the Treatment of Cancer
(Georgetown University, 2014)The clinical necessity of combining molecularly targeted agents to effectively treat cancer is clear. At the molecular level, the limitations of single-target inhibition due to the complexity and redundancy of oncogenic ... -
T Cell Based Immunotherapy Targeting Fibroblast Growth Factor Receptor 4 as a Therapeutic against Rhabdomyosarcoma
(Georgetown University, 2019)Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, has a low mutational burden with few actionable somatic targets. Fibroblast growth factor receptor 4 (FGFR4) is a candidate therapeutic target in ...
