Browsing Graduate Theses and Dissertations - Tumor Biology by Title
Now showing items 62-77 of 77
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Single-cell Biology Uncovers Cell Death as a Potential Driver of Tumor Heterogeneity and Fitness
(Georgetown University, 2021)Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous cancer type with limited treatment options. Identifying drivers of tumor heterogeneity may lead to better therapeutic options and favorable patient ... -
Social Isolation Stress, Obesity, and Breast Cancer Risk in Mice
(Georgetown University, 2014)Social isolation is a potent psychosocial stressor and is associated with obesity and increased breast cancer risk and mortality. In this thesis, I investigated the combined effects of social isolation stress and obesity ... -
Solute Carriers and Heat Shock Proteins Modulate Endocrine Therapy Resistance in Hormone Positive Breast Cancer
(Georgetown University, 2020)Resistance to endocrine therapies remains a major challenge for patients with estrogen receptor-positive (ER+) breast cancer. Adaptive reprogramming of cellular metabolism in response to treatment is one feature of this ... -
Studies of Breast Cancer Chemoprevention in Human High-Risk Primary Cells and Genetically Engineered Mouse Models
(Georgetown University, 2018)BRCA1 mutations have been associated with a 50-80% increased risk of developing breast cancer by the age of 70. Current recommendations for women carrying BRCA1 mutations include risk-reducing surgeries. Chemoprevention ... -
A Systems Approach to Understand the Molecular Synergy of Combined mTOR/Histone Deacetylase (HDAC) Inhibition in the Treatment of Cancer
(Georgetown University, 2014)The clinical necessity of combining molecularly targeted agents to effectively treat cancer is clear. At the molecular level, the limitations of single-target inhibition due to the complexity and redundancy of oncogenic ... -
T Cell Based Immunotherapy Targeting Fibroblast Growth Factor Receptor 4 as a Therapeutic against Rhabdomyosarcoma
(Georgetown University, 2019)Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, has a low mutational burden with few actionable somatic targets. Fibroblast growth factor receptor 4 (FGFR4) is a candidate therapeutic target in ... -
Targeting the Tumor Microenvironment to Enhance the Efficacy of Tumor-Targeted Antibody Therapy
(Georgetown University, 2014)Tumor-targeted antibody therapy has had a major impact on reducing morbidity and mortality in a wide range of cancers. Antibodies mediate their anti-tumor activity in part by activating immune effector cells; however, the ... -
Targeting WEE1 in Standard Therapy Resistant Estrogen Receptor Positive Breast Cancer
(Georgetown University, 2021)Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors that progress on antiestrogens are ... -
TCR Activation Impact On Chimeric Antigen Receptor Therapy Against Acute Lymphoblastic Leukemia
(Georgetown University, 2016)Tremendous progress has been achieved employing immunotherapy for B cell acute lymphoblastic leukemia (ALL), the most common diagnosis in children with cancer and a leading cause of cancer-related death. Recent trials using ... -
The APOE4 Mouse as a Model of Chemotherapy-induced Cognitive Impairments and Senescence
(Georgetown University, 2021)Cancer-related cognitive impairment (CRCI) occurs in 15-35% of breast cancer survivors and represents a major quality of life concern. CRCI has been linked to the APOE4 genotype, the strongest genetic risk factor for ... -
The Orphan Nuclear Receptor Estrogen-Related Receptor Beta in Triple-Negative Breast Cancer
(Georgetown University, 2019)Triple negative breast cancer (TNBC)/ basal-like breast cancer (BLBC) is a highly aggressive form of breast cancer. We previously reported that a small molecule agonist ligand for the orphan nuclear receptor estrogen-related ... -
The Roles of RARRES1 and SIRT1/2 in B Cell Function and Homeostasis
(Georgetown University, 2021)Upon cognate antigen encounter, naïve (antigen-inexperienced) B cells activate shifting from a state of quiescence to rapid clonal expansion and differentiation into germinal center (GC) B cells, antibody-secreting plasma ... -
Timing of dietary exposures and tamoxifen resistance in rats
(Georgetown University, 2016)In the USA, one in eight women develop invasive breast cancer at some point of her life, and 70% of the cancers are estrogen receptor positive and thus are treated with antiestrogen therapy. However, half of the treated ... -
TISSUE SPECIFIC PEPTIDE CONJUGATES FOR DRUG DELIVERY
(Georgetown University, 2015)Cytotoxic agents and targeted small molecules are used to treat cancer and disease, but are limited by systemic toxicity. The key to addressing this important issue is the development of a non-toxic, selective and specific ... -
Transcriptional Regulators in Cancer: Exploring YAP/TAZ-Driven Signaling Mechanisms and Super Enhancer Elements
(Georgetown University, 2020)Many cellular hallmarks of cancer are driven by dysregulation of their transcriptional programs. This work centers on exploring both regulatory elements of transcription and consequences of aberrant transcriptional activity ... -
TRANSGENERATIONAL INHERITANCE OF INCREASED BREAST CANCER RISK IN MOUSE OFFSPRING OF DAMS EXPOSED TO HIGH FAT N-6 POLYUNSATURATED FATTY ACID DIET DURING PREGNANCY
(Georgetown University, 2017)Maternal high fat (HF) intake before and/or during pregnancy increases female offsprings’ mammary cancer risk in several preclinical models. Here I studied if maternal HF intake during pregnancy cause transgenerational ...
