Browsing Graduate Theses and Dissertations - Tumor Biology by Creation Date
Now showing items 1-20 of 81
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IGFBP-3 mediates the effect of tumor suppressor NKX3.1 on prostate cancer cell proliferation
(Georgetown University, 2008) -
CADHERIN-11 MEDIATION OF TUMOR PROGRESSION AND INVASION IN POOR PROGNOSIS CANCERS: A VIABLE THERAPEUTIC TARGET
(Georgetown University, 2009)Loss of E-cadherin is considered a hallmark of epithelial carcinogenesis and has been well-studied to date. Likewise, increases in N-cadherin are known to lead to tumor progression and metastasis in various cancers. A ... -
The role of the chemokine receptor CXCR4 in EGFRvIII-expressing breast cancer
(Georgetown University, 2009) -
RARRES1 regulation of alpha-tubulin tyrosination, cytokinesis and vertebrate embryonic development
(Georgetown University, 2009) -
Molecular characterization of animal models of pheochromocytoma
(Georgetown University, 2009) -
DEREGULATED ESTROGEN RECEPTOR ALPHA-INITIATED PRENEOPLASIA AND ITS PROGRESSION: ROLE OF STAT5A AND CYCLIN D1
(Georgetown University, 2009)Deregulation of estrogen pathway has been linked to the pathophysiology of breast cancer. CERM (Conditional Estrogen Receptor alpha in Mammary epithelium) mice with deregulated ERalpha (ER) in the mammary epithelium develop ... -
BCL-2 family function in antiestrogen-resistant breast cancer cells
(Georgetown University, 2009) -
A multi-faceted approach to the detection and treatment of pancreatic cancer
(Georgetown University, 2010) -
A multi-faceted approach to the detection and treatment of pancreatic cancer
(Georgetown University, 2010) -
Identification and therapeutic targeting of novel transforming pathways in human glioblastoma multiforme
(Georgetown University, 2010) -
The Nuclear Function of the Splice Variant Amplified in Breast Cancer 1-Delta4 Contributes to its Oncogenicity
(Georgetown University, 2011)The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant of AIB1 called AIB1-Delta4 that ... -
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ... -
CDK inhibitor VMY-1-103 causes cell cycle arrest and apoptosis in cancer cell lines
(Georgetown University, 2012)The mammalian cell cycle is a tightly controlled process that -
THE IDENTIFICATION OF CELLULAR GENES ALTERED BY HTERT AND HPV-16 IN THE IMMORTALIZATION OF HUMAN KERATINOCYTES
(Georgetown University, 2012)Studies have shown that wild-type hTERT protein can functionally replace the HPV-16E6 protein, which cooperates with the viral E7 protein in the immortalization of primary keratinocytes. Previously, we made the surprising ... -
DAP12 impacts trafficking and surface stability of killer cell immunoglobulin-like receptors on natural killer cells
(Georgetown University, 2012)Killer cell immunoglobulin-like receptors (KIR) aid in the regulation of natural killer (NK) cell activity. In this study, the effect of the interaction between the two domain stimulatory KIR (KIR2DS) and their adapter, ... -
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ... -
EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein
(Georgetown University, 2012)Ewing sarcoma family of tumors (ESFT) consists of highly malignant tumors of the bone and soft tissue. Ninety-five percent of cases contain a balanced t(11;22) or t(21;22) rearrangement, combining the amino-terminus of ... -
The Human Papillomavirus Type 16 E5 Protein: Stress Signaling and Expression in Cervical Cancer Cell Lines
(Georgetown University, 2012)ABSTRACT -
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ...
