Role of Nag-1 and p75NTR in non-steroidal anti-inflammatory drug inhibition of prostate cancer cell migration
Thesis (Ph.D.)--Georgetown University, 2011.; Includes bibliographical references.; Text (Electronic thesis) in PDF format. This study explored the possibility of a shared mechanism of induction of p75NTR and Nag-1 by the NSAIDs ibuprofen and R-flurbiprofen in the PC-3 prostate cancer cell line. The functional role of Nag-1 induction in prostate cancer cells was also investigated. It was observed that Nag-1 induction following NSAID treatment is mediated by the p38 MAPK pathway and this induction is downstream of p75NTR induction. Further, it was demonstrated that decreased survival of NSAID-treated cells is dependent on induction of p75NTR, but not Nag-1. Investigation of NSAID inhibition of cell migration revealed that the decrease in cell migration upon treatment with these drugs is mediated by Nag-1 downstream of p75NTR. Collectively, these results demonstrate a role for Nag-1 in NSAID inhibition of prostate cancer cell migration, but not cell survival.
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