Role of Nag-1 and p75NTR in non-steroidal anti-inflammatory drug inhibition of prostate cancer cell migration
Thesis (Ph.D.)--Georgetown University, 2011.; Includes bibliographical references.; Text (Electronic thesis) in PDF format. This study explored the possibility of a shared mechanism of induction of p75NTR and Nag-1 by the NSAIDs ibuprofen and R-flurbiprofen in the PC-3 prostate cancer cell line. The functional role of Nag-1 induction in prostate cancer cells was also investigated. It was observed that Nag-1 induction following NSAID treatment is mediated by the p38 MAPK pathway and this induction is downstream of p75NTR induction. Further, it was demonstrated that decreased survival of NSAID-treated cells is dependent on induction of p75NTR, but not Nag-1. Investigation of NSAID inhibition of cell migration revealed that the decrease in cell migration upon treatment with these drugs is mediated by Nag-1 downstream of p75NTR. Collectively, these results demonstrate a role for Nag-1 in NSAID inhibition of prostate cancer cell migration, but not cell survival.
Showing items related by title, author, creator and subject.
Inhibition of Prostate Cancer Invasion by Small Molecule Antagonists of ERG and ETV1 Transcription Factors Rahim, Said (Georgetown University, 2013)Chromosomal translocations involving the ETS family of transcription factors are found in a majority of prostate cancers, including the most clinically aggressive forms. These translocations produce a chimeric gene, which ...
Navone, Stefania; Cristini, Silvia; Canzi, Laura; Parati, Eugenio A.; Invernici, Gloria (2010-01)Over the last decade, improvements in cancer therapies have prolonged the lives of cancer patients. Despite dramatic advances in imaging technology, surgical techniques, and adjuvant radio- and chemotherapy, the overall ...