Identification, pharmacology and anatomical localization of heteromeric neuronal nicotinic acetylcholine receptors in the rat hippocampus : effects of nicotine on nicotinic receptors expressed in rat primary cultured neurons
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DeDominicis, Kristen Elizabeth (Georgetown University, 2015)Nicotinic acetylcholine receptors (nAChRs) are present throughout the nervous system where they mediate and modulate neurotransmission. The α4β2* subtype is the most prevalent high affinity nAChR expressed in the brain. ...
Probing the Role of Neuronal Nicotinic Acetylcholine Receptors in Modulating In Vitro Hippocampal Network Dynamics Djemil, Sarra (Georgetown University, 2018)Nicotinic acetylcholine receptors (nAChRs), the first receptors to be identified, play varying and essential roles throughout the CNS. Both the endogenous ligand, acetylcholine, and exogenous ligand, nicotine, have been ...
Hussmann, Gregory Patrick (Georgetown University, 2012)Chronic nicotine administration increases the density of α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) in brain. Nicotine up-regulates these receptors in numerous research models, including cultured ...