Sorting nexin 5 and dopamine 1 receptor regulate insulin signaling and metablism in renal proximal tubule cells
Thesis (Ph.D.)--Georgetown University, 2011.; Includes bibliographical references.; Text (Electronic thesis) in PDF format. The mechanisms that regulate the renal degradation of insulin are unknown. This dissertation research tests the overall hypothesis that in the kidney, sorting nexin 5 (SNX5) and dopamine D1 receptor (D1R) regulate insulin receptor (IR) expression and insulin signaling pathway, as well as the insulin degrading enzyme (IDE). Two parallel objectives of this dissertation research are: 1) to investigate how SNX5 and D1R regulate the IR and insulin signaling pathway; and 2) to investigate how SNX5 and D1R regulate IDE and insulin degradation.
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