|dc.creator||Stollstorff, Melanie Louise.||en
|dc.identifier.other||APT-BAG: georgetown.edu.10822_553227.tar;APT-ETAG: e5b12a312a26ea12fd89d16f5b24828b||en
|dc.description||Thesis (Ph.D.)--Georgetown University, 2010.; Includes bibliographical
references.; Text (Electronic thesis) in PDF format. Deductive reasoning is influenced by
emotions and beliefs. It is unknown how factors relating to emotion and beliefs interact to
affect logical reasoning. This dissertation explored the nature of emotion-belief interactions
in relational reasoning using behavioral, genetic and neuroimaging techniques. In Study 1,
reasoning behavior was influenced by beliefs such that participants were less accurate and
slower to evaluate arguments in which the conclusion validity conflicted with beliefs, thereby
replicating the belief bias effect. Moreover, belief-bias interacted with emotional content
and serotonin transporter genotype; carriers of the short (S) allele of the serotonin
transporter gene (5-HTTLPR) had increased emotional belief bias relative to long (L) carriers.
Groups did not differ in non-emotional belief bias. In Study 2, I investigated the neural
basis for this emotion-belief interaction using functional magnetic resonance imaging (fMRI).
Healthy individuals with the S allele had decreased activation of right inferior frontal
cortex (rIFC) and increased activity in ventromedial prefrontal cortex (vmPFC) when reasoning
with emotional belief-logic conflict problems relative to L allele carriers. Anxiety was
positively correlated with activation of vmPFC in emotional belief-logic conflict reasoning.
These results have implications for depression and anxiety disorders, which are related to the
5-HTTLPR S allele, emotional reactivity, and deleterious beliefs.||en
|dc.source||Dept. of Psychology, Doctoral dissertations, 2010.||en
|dc.subject||Psychology, Experimental; Biology, Neuroscience; Logic||en
|dc.title||Modulation of reasoning bias and brain activation by serotonin transporter genotype
and emotional content||en