Show simple item record

Files in this item

Cover for SPECIFICITY OF INHIBITORY CONTROL OF CORTICAL INTERNEURONS IN LAYER 4 OF MOUSE SOMATOSENSORY BARREL CORTEX
dc.contributor.advisorHuntsman, Molly Men
dc.creatoren
dc.date.accessioned2013-05-17T18:58:01Zen
dc.date.available2014-05-17T04:10:08Zen
dc.date.created2009en
dc.date.issueden
dc.date.submitted01/01/2009en
dc.identifier.otherAPT-BAG: georgetown.edu.10822_558142.tar;APT-ETAG: 08bc0360fbe8e65fca0fe938992e3e2a; APT-DATE: 2017-02-07_14:23:54en
dc.identifier.urien
dc.descriptionPh.D.en
dc.description.abstractCortical processing of sensory information relies on a diversity of inhibitory control. This thesis examines the cell type specificity in layer 4 of mouse somatosensory barrel cortex of two understudied mechanisms of GABA inhibition: 1) tonic inhibition mediated by specific GABAA receptors, and 2) GABAB receptor mediated inhibition. Using whole-cell patch clamp techniques, we find that tonic GABAA inhibition is greatest in inhibitory neurons. This inhibition of inhibitory neurons produces a net excitatory effect. Within inhibitory neurons, there is additional diversity of tonic GABAA inhibition, with consequences for information processing, seen specifically in fast spiking (FS) mediated feed forward inhibition. GABAB receptor mediated inhibition of neurotransmitter release acts on both excitatory and inhibitory neurons, with the greatest effect seen in a non-FS interneurons. Paired recordings between synaptically coupled neurons show an approximate 50% inhibition at synapses with either excitatory or FS inhibitory interneurons presynaptic, while responses produced by non-FS cells were essentially abolished by activation of GABAB receptors. In contrast to tonic GABAA inhibition, in adult animals, inhibitory currents from activation of GABAB receptors is greatest in excitatory neurons, rather than inhibitory neurons. However, in younger animals, there is equal GABAB inhibition of non-FS inhibitory interneurons. This inhibition decreases with age, with potential implications for plasticity.en
dc.formatPDFen
dc.format.extent96 leavesen
dc.languageENen
dc.publisherGeorgetown Universityen
dc.sourceGeorgetown University-Graduate School of Arts & Sciencesen
dc.sourcePharmacologyen
dc.subjectelectrophysiologyen
dc.subjectGABA(A)en
dc.subjectGABA(B)en
dc.subjectGPCRen
dc.subjectsomatosensoryen
dc.subjecttonicen
dc.subject.lcshNeurosciencesen
dc.subject.otherBiology, Neuroscienceen
dc.titleSPECIFICITY OF INHIBITORY CONTROL OF CORTICAL INTERNEURONS IN LAYER 4 OF MOUSE SOMATOSENSORY BARREL CORTEXen
dc.typethesisen
gu.embargo.terms1-yearen


This item appears in the following Collection(s)

Show simple item record