Browsing Georgetown University Medical Center by Title
Now showing items 44-63 of 505
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Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ... -
BCL-2 family function in antiestrogen-resistant breast cancer cells
(Georgetown University, 2009) -
The Behavioral and Neural Basis of Emotional Face Processing in Atypically Developing Children and Adolescents
(Georgetown University, 2014)The ability to recognize, interpret, and respond appropriately to the affective facial expressions of others is an important component of non-verbal communication; when face-emotion recognition is impaired there can be ... -
Behavioral Flexibility in Autism Spectrum Disorder: The Role of Memory and Its Neural Correlates
(Georgetown University, 2020)Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social and behavioral deficits, including pronounced inflexibility. Behavioral interventions often fail to generalize, possibly due to difficulties ... -
Best Practice Peripheral Intravenous Line Management: An Exploration of Anesthesia Practitioners’ Knowledge of and Compliance with Infection Control Guidelines
(Georgetown University, 2020)Peripheral intravenous (IV) catheters are one of the most commonly used devices in healthcare, with nearly 200 million placed annually. While essential for patient care, they provide a direct route for microorganisms to ... -
Beta Radiation Response of SIRAD® Colorimetric Dosimeter vs. Theoretical Calculation of Beta Dose in the 5 to 25 rad Range
(Georgetown University, 2012)<bold>ABSTRACT -
Biblical Sources for Shakespeare's Sonnets 24 and 33, and for Henry VIII: Implications for de Vere's Authorship
(Shakespeare Fellowship, 2012) -
The Brain Basis of Arithmetic, Reading and Reading Disability
(Georgetown University, 2013)Reading and arithmetic, both foundational skills essential for classroom success, are symbolic systems that were invented relatively recently in regard to evolutionary history; so recently that the human brain has not ... -
Brain Oscillatory Dynamics of Lexical-Semantic Processing
(Georgetown University, 2013)Neuropsychological and imaging studies have shown that anterior and posterior brain areas are involved in the retrieval and selection of semantic representations, but it is not known how these areas dynamically interact ... -
BRCA1 localization to the telomere and its loss upon DNA damage
(Georgetown University, 2010) -
BRCA1-mimetic Compound NSC35446.HCl Inhibits IKKB Expression by Reducing Estrogen Receptor-α Occupancy in the IKKB Promoter and Inhibits NF-κB Activity in Antiestrogen-resistant Human Breast Cancer Cells
(Georgetown University, 2017)BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor--α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells -
Building Reslience to Biothreats: An Assessment of Unmet Core Global Health Security Needs
(EcoHealth Alliance, 2019)Global health security is the bulwark against catastrophic public health events. Building this security is a timely and urgent challenge for the world as it faces an increasing rate of emergent and re-emergent infectious ... -
CADHERIN-11 MEDIATION OF TUMOR PROGRESSION AND INVASION IN POOR PROGNOSIS CANCERS: A VIABLE THERAPEUTIC TARGET
(Georgetown University, 2009)Loss of E-cadherin is considered a hallmark of epithelial carcinogenesis and has been well-studied to date. Likewise, increases in N-cadherin are known to lead to tumor progression and metastasis in various cancers. A ... -
Calcium Signaling in Cardiac Myocytes: Contributions from Mitochondria, Sodium-Calcium Exchanger, and Ryanodine Receptor
(Georgetown University, 2013)This dissertation explores three critical players in the cardiac Ca2+ signaling pathway. First, I examined the role of mitochondria in Ca2+ signaling by generating a Ca2+ probe, mitycamE31Q, with 1.5μM affinity for ... -
Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ... -
CDK inhibitor VMY-1-103 causes cell cycle arrest and apoptosis in cancer cell lines
(Georgetown University, 2012)The mammalian cell cycle is a tightly controlled process that
