Browsing Georgetown University Medical Center by Title
Now showing items 94-113 of 505
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DAP12 impacts trafficking and surface stability of killer cell immunoglobulin-like receptors on natural killer cells
(Georgetown University, 2012)Killer cell immunoglobulin-like receptors (KIR) aid in the regulation of natural killer (NK) cell activity. In this study, the effect of the interaction between the two domain stimulatory KIR (KIR2DS) and their adapter, ... -
Defining the Factors that Regulate the Conversion to a Trailblazer Epithelial to Mesenchymal Transition State
(Georgetown University, 2021)Tumor heterogeneity resulting from the co-existence of phenotypically diverse tumor cellpopulations is a major contributor in the pathogenesis of several human malignancies. In addition to the steady acquisition of heritable ... -
Depression in primary care: Attitudes of novice advanced practice nurses
(Georgetown University, 2016)The burden of depression across the globe is estimated to be a leading cause of disability. In the U.S., a considerable portion of mental healthcare is delivered in the primary care setting. Barriers to achieve best practices ... -
DEREGULATED ESTROGEN RECEPTOR ALPHA-INITIATED PRENEOPLASIA AND ITS PROGRESSION: ROLE OF STAT5A AND CYCLIN D1
(Georgetown University, 2009)Deregulation of estrogen pathway has been linked to the pathophysiology of breast cancer. CERM (Conditional Estrogen Receptor alpha in Mammary epithelium) mice with deregulated ERalpha (ER) in the mammary epithelium develop ... -
DESIGN AND SYNTHESIS OF SMALL MOLECULE DISRUPTORS OF EWS-FLI1 IN EWING'S SARCOMA
(Georgetown University, 2014)Ewing's sarcoma (ES) consists of highly malignant tumors of the bone and soft tissues. Ninety-five percent of ES cases contain a balanced t(11;22)(q24;q12) translocation, combining the amino-terminus of EWS to the ... -
Determining the Isotopic Concentration of Uranium from Vector Representation of the Gamma Spectrum
(Georgetown University, 2014)DETERMINING THE ISOTOPIC CONCENTRATION OF URANIUM FROM VECTOR REPRESENTATION OF THE GAMMA SPECTRUM -
Development and Utilization of a Diagnostic Support Tool for Asthma within the Electronic Medical Record.
(2020)Asthma in childhood is a common and costly chronic disease.[1] Quality asthma care can lead to better control of asthma thus decreasing use of health services.[9,10] The gold standard for pediatric asthma diagnosis and ... -
Development of a Novel Transfection System to Study Regulation of Hepatitis Delta Virus RNAs by Hepatitis Delta Antigen
(Georgetown University, 2019)Hepatitis delta virus (HDV) is a unique pathogen that co-infects with hepatitis B virus and increase the severity of acute and chronic liver disease. HDV is a negative stranded RNA virus and produces three processed RNAs ... -
The development of bursting networks following chemical long term potentiation
(Georgetown University, 2012)Collective rhythmic dynamics from neurons are vital for cognitive functions but how neurons self-organize to produce such activity is not well understood. Attractor-based computational models are a theoretical framework ... -
Development of Eye Dosimeter Using Additive Manufacturing Techniques to Monitor Occupational Eye Lens Exposures to Interventional Radiologists
(Georgetown University, 2017)In this project, an eye dosimeter was designed for monitoring occupational lens of the eye exposures targeted to interventional radiologists who are often indirectly exposed to scattered radiation from the patient while ... -
Development of Novel Computational Methodologies for Analyzing Post-Processed Untargeted LC-MS Metabolomics Data
(Georgetown University, 2014)In recent years, the field of metabolomics has quickly risen to become a crucial platform for conducting biological research. Its unique capabilities, which provides unparalleled comprehensive quantitative insight into the ... -
DEVELOPMENT OF NOVEL COMPUTATIONAL METHODS FOR DRUG DISCOVERY AND REPURPOSING IN ONCOLOGIC DISEASES AND OTHER ILLNESSES
(Georgetown University, 2015)Targeting disease-related proteins is important for drug discovery, yet target-based method have not been fruitful. Bottlenecks involve: (1) establishing biologically valid drug- protein target associations, and (2) assessing ... -
Diagnositc Criteria Associated with a Cohort of Children Identified with Symptoms of Postinfectious Autoimmune Encephalopathy (PAE)
(Georgetown University, 2020)Postinfectious Autoimmune Encephalopathy (PAE) is well defined in the literature; however, a provider may be unaware of its existence or have a difficult time distinguishing the disorder from other neuropsychiatric conditions, ... -
Did Sir Walter Ralegh Have Access to an Early Draft of Venus and Adonis?
(Shakespeare Oxford Fellowship, 2012) -
Direct and Indirect Inhibition of the Mediodorsal Thalamus Affects Seizure Propagation and Cognition
(Georgetown University, 2019)Temporal lobe epilepsy (TLE) is one of the most common neurological disorders, and is characterized by spontaneous, recurrent seizures. Seizures in TLE do not propagate randomly, but instead follow anatomically constrained ... -
The Discovery of a Major New Literary Source for Shakespeare's Works in the de Vere Geneva Bible
(Shakespeare Fellowship, 2010) -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ...
