Browsing Georgetown University Medical Center by Title
Now showing items 240-259 of 505
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Laminin-1 mediates epigenetic control of the epithelial cadherin for breast cancer cells in three-dimensional culture
(Georgetown University, 2010) -
The Loss of an Institution: Mourning Chestnut Lodge
(Columbia University Press, 2013)"The unexpected loss of a client can be a lonely and isolating experience for therapists. While family and friends can ritually mourn the deceased, the nature of the therapeutic relationship prohibits therapists from ... -
Magnetic resonance imaging (MRI) studies of the human auditory brain : objects, sequences, and dysfunction
(Georgetown University, 2010) -
Mahanine Disrupts Androgen Receptor Signaling in Human Prostate Cancer Cells
(Georgetown University, 2014)Continued reliance on androgen receptor (AR) signaling is an established hallmark of prostate cancer and castration-resistant prostate cancer (CRPC). Recent findings implicate the androgen receptor splice variant, ARv7 in ... -
Mapping the Neurocognitive Architecture of Reading
(Georgetown University, 2021)Reading relies on at least partially dissociable sub-word (sublexical) and word-specific (lexical) processes, which are subserved by somewhat separable neural substrates. Beyond this broad dissociation between sublexical ... -
Matriptase as a Novel Therapeutic Target in Non-Hodgkin Lymphoma
(Georgetown University, 2018)Non-Hodgkin Lymphoma (NHL) is a heterogeneous group of cancers derived from lymphocytes that is increasing in incidence. Advances in genetic diagnostic techniques and the introduction of immunotherapy have allowed significant ... -
Matriptase Is A Reactive Oxygen Species (ROS) Biosensor that Contributes to ER-Negative Breast Cancer Proliferation And Migration
(Georgetown University, 2019)Matriptase is a type-II serine protease that is widely expressed in epithelial tissues and is known to play a role in normal epithelial cell integrity. Matriptase expression and activation are normally tightly regulated ... -
Mechanism of dopamine-mediated activation of BK channels in human coronary artery smooth muscle cells
(Georgetown University, 2008) -
Mechanisms Behind the GABA-Mediated Field Potential in Hippocampus in the in vitro 4-aminopyridine Model of Epilepsy
(Georgetown University, 2012)Local field potentials (LFPs) mediated by GABAergic transmission have been recorded from resected human epileptic brain tissue, as confirmed by blockade of these events upon exposure to GABAergic transmission antagonists, ... -
MECHANISMS CONTROLLING HUMAN NOROVIRUS POLYPROTEIN PROCESSING
(Georgetown University, 2015)Noroviruses (NoV) are the prevailing cause of nonbacterial acute gastroenteritis worldwide and pose a significant financial burden on healthcare systems. The human NoV ORF1 encodes a 200 kDa polyprotein which is cleaved ... -
Mechanisms of epithelial cell cancer generation: genetic risk factors on cancer progression investigated using in vivo models and at a single cell level
(Georgetown University, 2012)Loss of Brca1, loss of p53, AIB1/AIB1delta3 over-expression, and ERalpha; over-expression, are risk factors for breast cancer development. These risk factors influence on mammary gland development and breast cancer risk ... -
Mechanisms of HIV-1 gp120 Neurotoxicity: The Role of Microtubules
(Georgetown University, 2019)Despite the introduction of antiretroviral therapy in 1996, about 50% of HIV-positive individuals demonstrate cognitive impairments known as HIV-associated neurocognitive disorders (HAND). Although neurons cannot be infected ... -
Mechanisms of HIV-1 Tat Neurotoxicity: a role for mitochondria
(Georgetown University, 2018)Human immunodeficiency virus (HIV) infection of the central nervous system promotes neuronal injury and apoptosis culminating in HIV-associated neurocognitive disorders (HAND). Viral proteins, like transactivator of ... -
MECHANISMS OF OBESITY-RELATED HEPATOCARCINOGENSIS
(Georgetown University, 2017)Nearly a third of the US population is currently obese. The recent rise in liver cancer prevalence correlates with the obesity epidemic and non-alcoholic fatty liver disease (NAFLD). The underlying mechanisms behind the ... -
MECHANISMS OF RECOVERY IN PATIENTS WITH SEVERE ARM IMPAIRMENT AFTER STROKE
(Georgetown University, 2017)Background: Arm hemiparesis is a common consequence of stroke. Patients with more severe arm impairment demonstrate nonlesioned hemisphere activation during brain imaging of motor function. Determining lesion characteristic ... -
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ... -
Mechanisms Regulating Growth Progression of Salivary Gland Neoplasms Using Mucoepidermoid Carcenoma Primary Cells
(Georgetown University, 2017)Acquiring patient-derived primary cancer cells is a means towards individualized cancer treatment and a critical step for precision medicine. Strategies that allow efficient isolation of primary cells that enable genetic ... -
Megakaryocyte purinergic receptor electrophysiology, calcium dynamics and the effects of acetylsalicylic acid
(Georgetown University, 2010) -
Mentoring for Student Registered Nurse Anesthetists: An Exploratory Study in the Development of a Mentoring Program
(Georgetown University, 2020)Previous research suggests that mentoring benefits Student Registered Nurse Anesthetists (SRNAs) in many ways including decreasing stress levels and increasing academic retention rates. There is little research, however, ...
