Browsing Georgetown University Medical Center by Title
Now showing items 283-302 of 505
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NEURAL COMPUTATIONS UNDERLYING SPEECH RECOGNITION IN THE HUMAN AUDITORY SYSTEM
(Georgetown University, 2011)Current theories of speech perception in the human brain propose two separate, hierarchically organized cortical processing streams, a ventral and a dorsal stream. The ventral stream is generally believed to mediate acoustic ... -
THE NEURAL SUBSTRATES UNDERLYING BOTH SPELLING AND READING
(Georgetown University, 2012)Written language forms a cornerstone of human communication and understanding. In order to understand why written language can be used skillfully by some and not by others, it is important to investigate the neural basis ... -
Neuronal DNA Double Strand Break Damage and Repair Following Sublethal iGluR Activation, and the Neuroprotective Effects of Melatonin
(Georgetown University, 2013)DNA double strand break (DSB) damage is among the most lethal forms of DNA damage, and its repair in mature neurons remains largely unexamined, particularly following neuronal excitation. A major cause of DSBs is mediated ... -
NEUROPATHOLOGICAL AND BEHAVIORAL CHANGES FOLLOWING REPEAT MILD TRAUMATIC BRAIN INJURY
(Georgetown University, 2015)An estimated 1.7 million Americans will sustain a traumatic brain injury (TBI) every year with approximately two-thirds of those injuries being classified as a mild TBI (mTBI). Injury severity and outcome are affected by ... -
NEUROPEPTIDE Y RECEPTOR TYPE 5 AS A REGULATORY RECEPTOR IN NPY SYSTEM
(Georgetown University, 2012)Neuropeptide Y (NPY) is one of the most abundant peptides in the central and peripheral nervous system. It is involved in numerous physiological (e.g. energy and bone homeostasis) and pathophysiological processes (e.g. ... -
Neuroprotective signaling through metabotropic glutamate receptor 1
(Georgetown University, 2011) -
A New 1569 Poem by Arthur Golding,' Re-attributed to Edward de Vere (Shakespeare)
(Shakespeare Oxford Fellowship, 2013) -
New Molecular Properties of Metabotropic Glutamate Receptors
(Georgetown University, 2013)This thesis is divided into three distinct sections. The work in Chapter I was designed to describe two newly identified exons found in the GRM1 gene that encode a novel splice variant of metabotropic glutamate (mGlu) 1 ... -
Newly Discovered Works by “William Shake-Speare,” a.k.a. Edward de Vere
(Oxfreudian Press, 2014) -
Nonnavigational Spatial Memory Processing in the Medial Temporal Lobe and Goal-directed Behavior in Rhesus Macaques
(Georgetown University, 2020)The hippocampus and cortical areas of the medial temporal lobe have a critical role in navigational spatial memory, as has been well-established in rodent models. However, nonnavigational spatial memory is more difficult ... -
Noradrenergic modulation of functional brain networks underlying executive control
(Georgetown University, 2016)Executive control, the goal directed deployment of cognitive resources, depends critically on a class of neurotransmitters called catecholamines. One such catecholamine, norepinephrine, is theorized to facilitate cognition ... -
Novel Base Excision Repair and Hypoxanthine in Live Human Cells
(Georgetown University, 2018)Elucidating the mechanism of DNA damage and mutation is key to understating cancer genesis. In the first section of this thesis we examined base excision repair enzymes (BER) responsible for mitigating damage to DNA. BER ... -
Novel regulatory mechanisms of cardiac L-type calcium channel
(Georgetown University, 2010) -
Novel Relationships of Splicing Factors and Regulation in TMZ-Resistant Glioblastoma
(Georgetown University, 2019)Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ... -
A Novel Role for Fyn in ApoER2 Regulation
(Georgetown University, 2014)Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex, hippocampus, and cerebellum during development ... -
NOVEL ROLES FOR IRON-SULFUR CLUSTERS IN RED BLOOD CELL DEVELOPMENT AND HUMAN DISEASE
(Georgetown University, 2012)Iron-sulfur (Fe-S) clusters are versatile enzyme cofactors that are essential to all living organisms due to their diverse electron transfer and catalytic capabilities. In this collection of studies, we investigated the ... -
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ... -
The Nuclear Function of the Splice Variant Amplified in Breast Cancer 1-Delta4 Contributes to its Oncogenicity
(Georgetown University, 2011)The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant of AIB1 called AIB1-Delta4 that ...
