Browsing Georgetown University Medical Center by Title
Now showing items 314-333 of 505
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p15Ink4b Loss Impairs the Maturation and Activation of Conventional Dendritic Cells
(Georgetown University, 2012)p15Ink4b, an inhibitor of cyclin-dependent kinases, is a tumor suppressor frequently associated with hematological malignancies. Its inactivation through DNA methylation is one of the most prevalent epigenetic alterations ... -
Patient and Staff Attitudes toward Clothing Restrictions on a Pediatric Psychiatric Unit
(Georgetown University, 2019)Pediatric psychiatric inpatients are among the most vulnerable individuals in society. While the use of seclusion and restraint is well chronicled in the field of research in this population, there are limited literature ... -
PATIENT DOSE REDUCTION IN COMPUTED TOMOGRAPHY AT MEDSTAR GEORGETOWN UNIVERSITY HOSPITAL: OPTIMIZATION OF ABDOMINAL ADULT PROTOCOL AND TRAINING OF REFERRING PHYSICIANS
(Georgetown University, 2017)Dose reduction in computed tomography (CT) has two components, elimination of unnecessary scans and optimization of justified exams. Several scientific articles have been published addressing issues and techniques for ... -
Pazopanib Reduces Tau Pathology and Restores Astrocytes in a Novel Mouse Model of Neurodegenerative Tauopathy
(Georgetown University, 2017)Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing in prevalence, and there are currently no cures. Previous work from our group has ... -
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
(Georgetown University, 2016)A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries ... -
Perceptual Learning in the Somatosensory System: Neural Mechanisms of Vibrotactile Categorization and Acoustic-To-Vibrotactile Speech Sensory Substitution
(Georgetown University, 2019)The basic goal of sensory systems is to extract information from the environment in order to guide behavior. Historically, the field of neuroscience has focused on the visual system in the study of sensory processing and ... -
Perioperative Corneal Abrasion: An Exploration of Educational Intervention Effectiveness and Impact on Prevention Practices
(Georgetown University, 2020)Research has identified risk factors associated with the development of perioperative corneal abrasions.2-4 Evidence suggests preventative measures that can be utilized to prevent corneal abrasions, however a standardized ... -
Pharmacological Properties of alpha4beta2 and alpha3beta4 Nicotine Acetylcholine Receptors: Ligand Binding, Activation, Desensitization, and Interspecies Differences
(Georgetown University, 2014)Smoking cessation medications using nicotinic ligands, including nicotine, cytisine, and varenicline, have traditionally revolved around selective activation of alpha4beta2 nicotinic acetylcholine receptors (nAChRs). ... -
Phototransfer thermoluminescence applied to the re-estimation of low dose levels of ionizing radiation for personnel dosimetry
(Georgetown University, 2010) -
Pilot Program to Improve Transfer of Care Between Neurosurgical and Outpatient Neurology Teams Following Implantation of an Intrathecal Baclofen Pump
(Georgetown University, 2016)PILOT PROGRAM TO IMPROVE TRANSFER OF CARE BETWEEN NEUROSURGICAL AND OUTPATIENT NEUROLOGY TEAMS FOLLOWING IMPLANTATION OF AN INTRATHECAL BACLOFEN PUMP -
A Pilot Quality Improvement Project to Introduce Utilization of an Electronic Bone Health Order Set in a Population of Hospitalized Pediatric Patients Identified at Risk for Fractures
(Georgetown University, 2016)Heightened risk for secondary osteoporosis and subsequent vulnerability to low impact fractures is often observed in children with complex health needs (CCHNs). This susceptibility, and an increased incidence of low-impact ... -
A Pilot Study to Evaluate the Effectiveness of the National Diabetes Prevention Program in an Urban Medically Underserved Community
(Georgetown University, 2016)This study evaluated the effectiveness of participation in the National Diabetes Prevention Program (NDPP) for weight reduction in a sample of prediabetic individuals in an urban medically underserved community. The NDPP ... -
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ... -
Predicting Disease Course in Bladder Cancer: STAG2 as a Prognostic Biomarker
(Georgetown University, 2019)Bladder cancer is the fifth most common cancer in the United States and the fourth most common in men, with >80,000 new cases annually. While most tumors can be surgically resected, as many as 70% of these tumors will ... -
Prenatal Care in the United States: Perceptions of Resettled Bhutanese-Nepali Refugees
(Georgetown University, 2021)The Bhutanese-Nepali community in the United States, estimated to be greater than 100,000, has been fleeing religious and ethnic persecution since the 1980s. Ohio ranks fifth in the United States in the number of resettled ... -
Prion properties and structural analysis of Candida albicans and Candida glabrata Ure2 proteins
(Georgetown University, 2010)Prions are infectious proteins first implicated as causative agents of scrapie and kuru disease. These diseases are characterized by spongiform brain pathology caused by toxic amyloid filament deposition. Our goal is to ... -
Probing The Flavivirus Life Cycle: Repurposing Amodiaquine as an Inhibitor of Flavivirus Infectivity and Functional Analysis of Flaviviral NS5 in 5'Capping
(Georgetown University, 2013)Dengue virus serotypes 1-4 (DENV1-4) are transmitted by mosquitoes and are the most frequent cause of arboviral infections in the world. Neither vaccine nor antiviral drug is currently available. In this study, we discovered ... -
Probing the Role of Neuronal Nicotinic Acetylcholine Receptors in Modulating In Vitro Hippocampal Network Dynamics
(Georgetown University, 2018)Nicotinic acetylcholine receptors (nAChRs), the first receptors to be identified, play varying and essential roles throughout the CNS. Both the endogenous ligand, acetylcholine, and exogenous ligand, nicotine, have been ...
