Browsing Georgetown University Medical Center by Title
Now showing items 347-366 of 505
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Radiation Dose to the Lens of the Eye in US Navy Medical Workers
(Georgetown University, 2021)In 2012, the International Committee for Radiation Protection (ICRP) published a report recommending a change in the allowable lens dose equivalent from 150 mSv per year to 20 mSv per year averaged over five years not to ... -
The Radiosensitizing Potential of Rigosertib and Dinaciclib in Ewing's Sarcoma Cells
(Georgetown University, 2015)Ewing’s sarcoma is the second most frequent bone cancer. However, it is still a relatively uncommon cancer, with only approximately 225 new cases diagnosed in patients under 20 years old each year in North America. Despite ... -
Rapid, Non-Classical Mechanism of Leukocyte Recruitment to Staphylococcus Aureus Skin Infection
(Georgetown University, 2020)Swift recruitment of phagocytic leukocytes is critical to prevent infections when bacteria breach through the protective layers of the skin. While this process is commonly believed to be dependent on the prior activation ... -
RARRES1 Modulation of Tubulin Deglutamylation Regulates Metabolism and Cell Survival
(Georgetown University, 2018)One of the driving mechanisms of cancer progression is the reprogramming of metabolic pathways in intermediary metabolism. Cancers increase their energy expenditure by increasing ATP production for utilization in anabolic ... -
RARRES1 regulation of alpha-tubulin tyrosination, cytokinesis and vertebrate embryonic development
(Georgetown University, 2009) -
Reality as an Inkblot: Looking at the Trauma Literature.
(Guilford Press, 2004) -
Recognition Memory in Amnestic Mild Cognitive Impairment
(Georgetown University, 2014)A detailed characterization of the memory impairment in amnestic mild cognitive impairment (aMCI) is important both clinically and in the interests of research. The progressive nature of dementia and the fact that neuronal ... -
REGULATION AND STOICHIOMETRY OF α4β2* NEURONAL NICOTINIC RECEPTORS
(Georgetown University, 2015)Nicotinic acetylcholine receptors (nAChRs) are present throughout the nervous system where they mediate and modulate neurotransmission. The α4β2* subtype is the most prevalent high affinity nAChR expressed in the brain. ... -
Regulation of Angiotensin Type 1 Receptor Function by an Upstream Short Open Reading Frame (sORF) in the mRNA 5' Leader Sequence
(Georgetown University, 2019)The angiotensin type 1 receptor (AT1R) plays a critical role in blood pressure control. In this study, we investigated the role of an upstream short open reading frame (sORF) in AT1aR signaling. We investigated Angiotensin ... -
Regulation of cadherin-11 by GSK3 inhibition and TGFbeta1 treatment in cancer cells
(Georgetown University, 2008) -
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ... -
Regulation of Neuronal Nicotinic Receptor Expression by Novel Ligands and Mechanisms
(Georgetown University, 2012)Chronic nicotine administration increases the density of α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) in brain. Nicotine up-regulates these receptors in numerous research models, including cultured ... -
Regulation of striatal medium spiny neuron GABAA receptor mediated tonic current
(Georgetown University, 2010) -
Regulation of telomerase by genistein in human prostate cancer cells
(Georgetown University, 2008) -
Regulation of the Complement System by Toxoplasma gondii Surface Coat Proteins SRS25, SRS29C, and SRS57
(Georgetown University, 2019)Very little is known about how the protozoan parasite Toxoplasma gondii overcomes the complement system to establish infection. In this dissertation, I found significant differences in C3b deposition between T. gondii Type ... -
Regulators of Cancer Cell Vascular Invasion and Malignancy
(Georgetown University, 2018)A metastasizing cancer cell will experience a series of diverse and often lethal selective pressures as it travels from a primary tumor to a distant organ site. Two crucial events in this multistep journey encompass cancer ... -
THE REGULATORY ROLES OF GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE (GILT) IN CELLULAR REDOX HOMEOSTASIS
(Georgetown University, 2011)Redox regulation is critical for a number of cellular functions and has been implicated in the etiology and progression of cardiovascular diseases, neurodegenerative diseases, and cancer. It has been shown that in the ... -
RELATIONSHIP OF THE METABOLOMIC PROFILING IN BLOOD TO SMOKING BEHAVIOR
(Georgetown University, 2012)Better biomarkers of cancer risk are needed for smokers to enhance early detection and support the FDA as it considers cigarette performance standards and evaluate health claims for modified tobacco products. Metabolomics ...
