Browsing Georgetown University Medical Center by Title

“The 1574 Mirror for Magistrates is a Possible Source for “Feath’red King” in Shakespeare’s ‘The Phoenix and the Turtle.’”.

Waugaman, Richard M. (Manchester University Press, 2014)

A 1578 Poem about Edward de Vere [Shakespeare]

Waugaman, Richard M. (2014)

9-cis-retinoic acided mediated endothelial transdifferentiation in breast cancer cells

Prahalad, Priya. (Georgetown University, 2008)

A-ephrins in Neuropsychiatric Spectrum Disorder Models

Wurzman, Rachel P. (Georgetown University, 2014)

Neuropsychiatric spectrum disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are frequently comorbid and exhibit overlapping abnormalities in both behavioral symptoms and ...

Cover for Acidic phospholipid deficiency results in an inhibition of chromosomal replication and cell-cycle specific arrest in Escherichia coli

Acidic phospholipid deficiency results in an inhibition of chromosomal replication and cell-cycle specific arrest in Escherichia coli

Fingland, Nicholas Kyle (Georgetown University, 2012)

Beyond the simplistic function as an environmental barrier, lipids have a variety of functions. The wealth of knowledge available on Escherichia coli (E. coli), and its small subset of lipid species, makes it an ideal ...

The Acquisition of Productive Rules in Child and Adult Language Learners

Schuler, Kathryn D (Georgetown University, 2017)

In natural language, evidence suggests that, while some rules are productive (regular), applying broadly to new words, others are restricted to a specific set of lexical items (irregular). Further, the literature suggests ...

Activation of estrogen receptor-alpha by nitrite

Storchan, Geoffrey (Georgetown University, 2012)

Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ...

ACTIVITY-DEPENDENT REGULATION OF AMYLOID PRECURSOR PROTEIN (APP) BY POLO-LIKE KINASE 2 (PLK2): NOVEL ROLES IN SYNAPTIC PLASTICITY

Lee, Ji Soo (Georgetown University, 2016)

The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ...

ACTIVITY-INDUCIBLE KINASE PLK2 REGULATES APP AMYLOIDOGENIC PROCESSING AND Aβ MEDIATED SYNAPTIC DEPRESSION

Lee, YeunKum (Georgetown University, 2012)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces Aβ peptides, the major component of hallmark AD senile ...

Age- and Experience-Dependent Modulation of Coherent Visual Motion Processing

Taylor, Caitlin (Georgetown University, 2016)

Visual motion processing dysfunction has been observed in developmental dyslexia, but the nature of the relationship between this dorsal stream function and the reading difficulties observed in dyslexia is unclear. This ...

Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to its HLA-C Ligand

Frazier, William Robinson (Georgetown University, 2013)

Although extensive homology exists between their extracellular domains, natural killer cell inhibitory receptors KIR2DL2*001 and KIR2DL3*001 have previously been shown to differ substantially in their HLA-C binding avidity. ...

Alpha-synuclein and its direct effects on microglial activation

Beraud, Dawn Altia (Georgetown University, 2013)

Accumulation, deposition and dysfunction of α-synuclein occur in a class of neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system ...

ALPHA-SYNUCLEIN AND THE MULTIPLE HIT HYPOTHESIS OF PARKINSON'S DISEASE

Feng, Li (Georgetown University, 2012)

Alpha-synuclein has been linked to the pathogenesis of Parkinson's disease and other synucleinopathies through its propensity to form toxic oligomers. The exact mechanism for oligomeric synuclein-directed cell vulnerability ...

ALTERATION OF MAMMARY GLAND DEVELOPMENT AND GENE EXPRESSION BY IN UTERO EXPOSURE TO METALLOESTROGENS

Parodi, Daniela Alida (Georgetown University, 2012)

Early life exposure to estrogens and estrogen like contaminants in the environment are thought to increase the risk of developing breast cancer due to the early onset of puberty in the exposed female. However, the results ...

Cover for Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets

Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets

Alex, Deepu (Georgetown University, 2011)

A steady increase in the incidence of fungal infections has been observed over the past few decades, and treatment remains challenging especially for immuno-compromised populations. Identification of the ideal therapeutic ...

An Assessment of Common Approaches to Estimating Peak Skin Dose Rresulting from Fluoroscopically Guided Interventions

Smith, Caleb Martin (Georgetown University, 2017)

Fluoroscopy guided procedures are increasing in complexity, and with that, Peak Skin Doses (PSD) that produce cutaneous radiation injury are a growing concern. Direct measurement of PSD is possible, but the decision to do ...

An Exploration of a Substance Abuse Treatment Program and Its Effects on Opioid Addicted Adults’ Ability to Maintain Recovery

Muncy, Karen Marie (Georgetown University, 2018)

As deaths related to opioids continue to increase across the country, with more than 41,000 deaths in 2016, a dark cloud looms over Florida as the state strives to contain the epidemic. There were 779 deaths related to ...