Browsing Georgetown University Medical Center by Title
Now showing items 1-20 of 489
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“The 1574 Mirror for Magistrates is a Possible Source for “Feath’red King” in Shakespeare’s ‘The Phoenix and the Turtle.’”.
(Manchester University Press, 2014) -
9-cis-retinoic acided mediated endothelial transdifferentiation in breast cancer cells
(Georgetown University, 2008) -
A Comparison of Student Nurse Anesthetists’ Perceptions of Regional Anesthesia Skill and Knowledge Acquisition Utilizing Cadavers Versus Non-Cadaver Models
(Georgetown University, 2020)Due to the expansion of healthcare to a larger population and the increased need for more anesthesia providers, Certified Registered Nurse Anesthetists (CRNAs) are practicing to the full extent of their education and ... -
A Comparison of Student Registered Nurse Anesthetists Pharmacology Knowledge Acquisition and Long-Term Retention Following Exposure to Didactic Instruction and Experiential Learning Versus Didactic Instruction Alone
(Georgetown University, 2020)High fidelity simulation (HFS) is a useful method to teach practical information without the risk of harming a live patient. It is a teaching method used in at least half of all nurse anesthesia programs, but not generally ... -
A Translational Investigation of Discoidin Domain Receptor 1 Inhibition as a Novel Therapeutics Strategy in Neurodegenerative Disease
(Georgetown University, 2021)Neurodegenerative diseases (ND) are gaining recognition as imminent health crises. The greatest unmet need in neurodegeneration is a disease modifying therapy, but the failures of drug development have not been for a lack ... -
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ... -
A-ephrins in Neuropsychiatric Spectrum Disorder Models
(Georgetown University, 2014)Neuropsychiatric spectrum disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are frequently comorbid and exhibit overlapping abnormalities in both behavioral symptoms and ... -
Acidic phospholipid deficiency results in an inhibition of chromosomal replication and cell-cycle specific arrest in Escherichia coli
(Georgetown University, 2012)Beyond the simplistic function as an environmental barrier, lipids have a variety of functions. The wealth of knowledge available on Escherichia coli (E. coli), and its small subset of lipid species, makes it an ideal ... -
The Acquisition of Productive Rules in Child and Adult Language Learners
(Georgetown University, 2017)In natural language, evidence suggests that, while some rules are productive (regular), applying broadly to new words, others are restricted to a specific set of lexical items (irregular). Further, the literature suggests ... -
Activation of estrogen receptor-alpha by nitrite
(Georgetown University, 2012)Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ... -
ACTIVITY-DEPENDENT REGULATION OF AMYLOID PRECURSOR PROTEIN (APP) BY POLO-LIKE KINASE 2 (PLK2): NOVEL ROLES IN SYNAPTIC PLASTICITY
(Georgetown University, 2016)The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ... -
ACTIVITY-INDUCIBLE KINASE PLK2 REGULATES APP AMYLOIDOGENIC PROCESSING AND Aβ MEDIATED SYNAPTIC DEPRESSION
(Georgetown University, 2012)Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces Aβ peptides, the major component of hallmark AD senile ... -
Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
(Georgetown University, 2019)As the resident macrophage of the central nervous system, microglia are in a uniquely privileged position to both affect and be affected by neuroinflammation, neuronal activity and injury, which are all hallmarks of seizures ... -
Addressing Thoracic Cancers: Biomarker and Pre-Clinical Drug Discovery in Non-Small Cell Lung Cancer and Thymic Carcinoma
(Georgetown University, 2020)Thoracic cancer is a term that encompasses numerous malignancies within the thoracic cavity; the term includes malignancies such as lung cancers and thymic epithelial tumors. Lung cancers are the leading cause of cancer ... -
Adolescent Neurocognitive Maturity Mediates Paths to Altered Social Norms and Vulnerability in Emerging Adulthood
(Georgetown University, 2020)The transitional period between adolescence and adulthood is a high-risk period for social strain and adversity leading to experiences of violence and altered normative civic beliefs. In this dissertation, I examine cognitive ... -
Age- and Experience-Dependent Modulation of Coherent Visual Motion Processing
(Georgetown University, 2016)Visual motion processing dysfunction has been observed in developmental dyslexia, but the nature of the relationship between this dorsal stream function and the reading difficulties observed in dyslexia is unclear. This ... -
AIB1 and ANCO1 Regulate YAP/TEAD Signaling in Early Stage Basal Breast Cancer
(Georgetown University, 2019)The progression of ductal carcinoma in-situ (DCIS) to locally invasive breast cancer precedes distant metastases and disease lethality. The Amplified In Breast cancer 1 (AIB1) transcription coactivator becomes overexpressed ... -
Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to its HLA-C Ligand
(Georgetown University, 2013)Although extensive homology exists between their extracellular domains, natural killer cell inhibitory receptors KIR2DL2*001 and KIR2DL3*001 have previously been shown to differ substantially in their HLA-C binding avidity. ... -
Alpha-synuclein and its direct effects on microglial activation
(Georgetown University, 2013)Accumulation, deposition and dysfunction of α-synuclein occur in a class of neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system ...
