Search Full Text
Now showing items 1-10 of 48
α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES
(Georgetown University, 2015)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...
EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)
Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...
NEUROPEPTIDE Y RECEPTOR TYPE 5 AS A REGULATORY RECEPTOR IN NPY SYSTEM
(Georgetown University, 2012)
Neuropeptide Y (NPY) is one of the most abundant peptides in the central and peripheral nervous system. It is involved in numerous physiological (e.g. energy and bone homeostasis) and pathophysiological processes (e.g. ...
The structures, biological activity, and mechanistic studies of novel marine-derived antibacterial compounds
(Georgetown University, 2012)
Due to the rise and global proliferation in drug-resistant bacterial infections, we face a continuing need to have a supply of novel antibacterial agents that are not just more potent or useful against a broader spectrum ...
Modulation of dopamine transporter trafficking by the synuclein family of proteins
(Georgetown University, 2013)
Dopamine signaling is controlled in part by pre-synaptic re-uptake of dopamine through the dopamine transporter (DAT), and is therefore regulated by the distribution of DAT to the cell surface. DAT trafficking is modulated ...
Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
Activation of estrogen receptor-alpha by nitrite
(Georgetown University, 2012)
Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ...
Development of Novel Computational Methodologies for Analyzing Post-Processed Untargeted LC-MS Metabolomics Data
(Georgetown University, 2014)
In recent years, the field of metabolomics has quickly risen to become a crucial platform for conducting biological research. Its unique capabilities, which provides unparalleled comprehensive quantitative insight into the ...
In Vivo DNA Repair Mechanisms and Carcinogenesis
(Georgetown University, 2014)
The maintenance of the genome is an important barrier to carcinogenesis, and one of the major cellular pathways involved in genome maintenance is DNA repair. There are several types of DNA repair pathways, but one type, ...
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ...