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EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)
Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...
Timing of Dietary Exposures on Risk of Reproductive Cancer
(Georgetown University, 2014)
TIMING OF DIETARY EXPOSURES ON RISK OF REPRODUCTIVE CANCER
THE IDENTIFICATION OF CELLULAR GENES ALTERED BY HTERT AND HPV-16 IN THE IMMORTALIZATION OF HUMAN KERATINOCYTES
(Georgetown University, 2012)
Studies have shown that wild-type hTERT protein can functionally replace the HPV-16E6 protein, which cooperates with the viral E7 protein in the immortalization of primary keratinocytes. Previously, we made the surprising ...
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ...
The Human Papillomavirus Type 16 E5 Protein: Stress Signaling and Expression in Cervical Cancer Cell Lines
(Georgetown University, 2012)
ABSTRACT
Interferon Regulatory Factor-1 (IRF1) Signaling Regulates Apoptosis and Autophagy to Determine Endocrine Responsiveness and Cell Fate in Human Breast Cancer
(Georgetown University, 2013)
Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor and pivotal regulator of cell fate in cancer cells. While IRF1 is known to possess tumor suppressive activities, the role of IRF1 in mediating apoptosis ...
The Molecular Determinants of Tumor Cell Modulation of Immune Selection
(Georgetown University, 2015)
Over the past century, the identification of molecules that tumor cells utilize to manipulate the activation or survival of immune cells has proven difficult. Expression analyses have helped to discover the downregulation ...
TISSUE SPECIFIC PEPTIDE CONJUGATES FOR DRUG DELIVERY
(Georgetown University, 2015)
Cytotoxic agents and targeted small molecules are used to treat cancer and disease, but are limited by systemic toxicity. The key to addressing this important issue is the development of a non-toxic, selective and specific ...
Intercellular communication in neuronal elaboration and circuit formation: a role for EphA signaling
(Georgetown University, 2012)
The mammalian cerebral cortex begins to take shape during embryonic development. The generation of cortical neurons is stereotyped: initial proliferation of cells is followed by differentiation of progeny into neurons and ...
Human APOE4 Affects Microglial Reactivity and Spatial Cognition in a Mouse Model of Alzheimer's Disease Risk
(Georgetown University, 2015)
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder that results in declarative memory deficits. Apolipoprotein e4 (APOE-ε4) is the strongest genetic risk factor for developing AD, and influences ...