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ELUCIDATING THE ROLE OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEIN 2 IN THE PATHOGENESIS OF TYPE 2 DIABETES
(Georgetown University, 2013)
The prevalence of type 2 diabetes mellitus (T2D) has reached epidemic proportions, making it a major public health concern. T2D is known to be highly heritable, but until recently its genetic architecture was largely ...
ACTIVITY-DEPENDENT REGULATION OF AMYLOID PRECURSOR PROTEIN (APP) BY POLO-LIKE KINASE 2 (PLK2): NOVEL ROLES IN SYNAPTIC PLASTICITY
(Georgetown University, 2016)
The brain uses a special feature, synaptic plasticity, for learning and memory. As forms of synaptic plasticity, associative plasticity, long-term potentiation (LTP) and long-term depression (LTD), is a positive feedback ...
BRCA1-mimetic Compound NSC35446.HCl Inhibits IKKB Expression by Reducing Estrogen Receptor-α Occupancy in the IKKB Promoter and Inhibits NF-κB Activity in Antiestrogen-resistant Human Breast Cancer Cells
(Georgetown University, 2017)
BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor--α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells
Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
(Georgetown University, 2016)
A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries ...
Activation of estrogen receptor-alpha by nitrite
(Georgetown University, 2012)
Recent studies show that the anion nitrite binds to and activates estrogen receptor-alpha (ERα). Mutational analysis and molecular modeling identified three potential nitrite binding sites in the ligand binding domain ...
CDK inhibitor VMY-1-103 causes cell cycle arrest and apoptosis in cancer cell lines
(Georgetown University, 2012)
The mammalian cell cycle is a tightly controlled process that
In Vivo DNA Repair Mechanisms and Carcinogenesis
(Georgetown University, 2014)
The maintenance of the genome is an important barrier to carcinogenesis, and one of the major cellular pathways involved in genome maintenance is DNA repair. There are several types of DNA repair pathways, but one type, ...
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)
An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ...
The Molecular Determinants of Tumor Cell Sensitivity and Resistance to Antibody-Dependent Cellular Cytotoxicity (ADCC)
(Georgetown University, 2013)
Monoclonal antibodies represent the vanguard of targeted therapy due to their specificity and versatility. Aside from disrupting tumor cell survival and proliferation through cell surface receptor interactions, antibodies ...