Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ...

Breast cancer is the most diagnosed cancer and the most frequent cause of cancer mortality in women worldwide. Immunoreactive assays as well as gene expression profiling of breast cancer have shown a high degree of ...

Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ...

The angiotensin type 1 receptor (AT1R) plays a critical role in blood pressure control. In this study, we investigated the role of an upstream short open reading frame (sORF) in AT1aR signaling. We investigated Angiotensin ...

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, has a low mutational burden with few actionable somatic targets. Fibroblast growth factor receptor 4 (FGFR4) is a candidate therapeutic target in ...

Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. We have utilized a patient-derived bladder cancer xenograft (PDX) platform to characterize ...

Here we demonstrate the efficacy of palbociclib in targeting the cell cycle kinase CDK4/6 and canonical pathways downstream in both normal breast epithelial (MCF10A) and early stage breast cancer cells (MCFDCIS) resulting ...