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Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ...
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)
Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ...
Drivers of cancer cell invasion and metastasis
(Georgetown University, 2012)
Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, extravasation at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and ...
Role of the Ubiquitin Proteasome System in the Regulation of V(D)J Recombination
(Georgetown University, 2012)
V(D)J recombination, the only known site specific DNA rearrangement in vertebrates, is the process that is responsible for the development of vertebrate adaptive immunity. It mediates the assembly of antigen receptor genes ...
ALTERATION OF MAMMARY GLAND DEVELOPMENT AND GENE EXPRESSION BY IN UTERO EXPOSURE TO METALLOESTROGENS
(Georgetown University, 2012)
Early life exposure to estrogens and estrogen like contaminants in the environment are thought to increase the risk of developing breast cancer due to the early onset of puberty in the exposed female. However, the results ...
Molecular Features of Human Bone Marrow Stem Cells
(Georgetown University, 2012)
Understanding the quality and quantity of resident bone marrow cells as well as circulating bone marrow derived cells (BMDC) are key to unlocking the complexity of their contribution to physiological hemostasis or pathological ...
THE CX3CR1+ LAMINA PROPRIA DENDRITIC CELL: MASTER SENTINEL OF THE TERMINAL ILEUM
(Georgetown University, 2012)
The CX3CR1+ lamina propria dendritic cell (LPDC) of the terminal ileum provides a unique sentinel role, critical for intestinal health. Here, we demonstrate that three Crohn's disease associated single nucleotide polymorphisms ...
ROLE OF BTG2 IN THE ANTIOXIDANT RESPONSE IN HUMAN BREAST EPITHELIAL CELLS.
(Georgetown University, 2012)
BTG2, a member of antiproliferative gene family BTG/TOB, has been implicated in cell cycle regulation, normal development and tumor suppression. However, the underlying mechanism(s) by which BTG2 regulates these processes ...