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α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES
(Georgetown University, 2015)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...
EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)
Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...
CIRCUMVENTING ANTIGEN LOSS TO POTENTIATE CANCER IMMUNOTHERAPY
(Georgetown University, 2015)
Cancer cells become resistant to monoclonal antibody (mAb) therapy when they lose the cell surface antigens that mAbs target. To circumvent immune escape and maximize the efficacy of mAb therapy, new approaches to mitigate ...
The Radiosensitizing Potential of Rigosertib and Dinaciclib in Ewing's Sarcoma Cells
(Georgetown University, 2015)
Ewing’s sarcoma is the second most frequent bone cancer. However, it is still a relatively uncommon cancer, with only approximately 225 new cases diagnosed in patients under 20 years old each year in North America. Despite ...