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The Response of Cancer Cells to Local Changes in Extracellular Stiffness
(Georgetown University, 2017)
Durotaxis is a mechanism of directed cell migration in which cells respond to gradients of extracellular stiffness. While durotaxis has been predominantly characterized in a subset of mesenchymal cells, the potential for ...
MECHANISMS OF OBESITY-RELATED HEPATOCARCINOGENSIS
(Georgetown University, 2017)
Nearly a third of the US population is currently obese. The recent rise in liver cancer prevalence correlates with the obesity epidemic and non-alcoholic fatty liver disease (NAFLD). The underlying mechanisms behind the ...
Distinct Roles for EphA7 Isoforms in Cortical Dendritic Elaboration and Synapse Formation
(Georgetown University, 2017)
The cerebral cortex consists of complex circuitry that directs diverse functions. Development of the cortex relies upon precise coordination between inherent genetic programs and environmental signals to create distinct ...