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The Mechanism of Actin Remodeling by the N-BAR Domain of ASAP1
(Georgetown University, 2020)
Ability to initiate key cellular events relies on engaging cytoskeletal machinery, including remodeling of the actin cytoskeleton and its interactions with the extracellular matrix. Actin remodeling is a dynamic process, ...
Investigation of Potential Targets of Chemotherapy in Ewing Sarcoma and Prostate Cancer
(Georgetown University, 2020)
Cancer-specific features are attractive targets for novel chemotherapies. In Ewing sarcoma, two characteristic features are the cell-surface protein CD99 and the EWS-FLI1 fusion protein. CD99 expression in Ewing sarcoma ...
Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Robustly Generated from Healthy Donor Blood
(Georgetown University, 2020)
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ...
Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events
(Georgetown University, 2020)
Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ...
Solute Carriers and Heat Shock Proteins Modulate Endocrine Therapy Resistance in Hormone Positive Breast Cancer
(Georgetown University, 2020)
Resistance to endocrine therapies remains a major challenge for patients with estrogen receptor-positive (ER+) breast cancer. Adaptive reprogramming of cellular metabolism in response to treatment is one feature of this ...
The Role of T-LAK Cell-Originated Protein Kinase (TOPK) in Modulating Prostate Cancer Stemness and Androgen Independence
(Georgetown University, 2020)
The predominant clinical challenge in the treatment of prostate cancer (CaP) is how to differentiate aggressive CaP from indolent ones. Previously, our lab has demonstrated that a protein kinase, T-LAK cell-originated ...