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Enhancing Anti-Cancer Properties of Human Natural Killer Cells
(Georgetown University, 2021)
Immunotherapy has revolutionized cancer treatment. Certain immunotherapies, such as immune checkpoint inhibitors and CAR-T cell therapy, provide long lasting remissions. Unfortunately, the majority of tumors are unresponsive ...
Targeting WEE1 in Standard Therapy Resistant Estrogen Receptor Positive Breast Cancer
(Georgetown University, 2021)
Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors that progress on antiestrogens are ...
Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (CICS) Derived from Germline Pluripotent Stem Cells (HGPSCS) to Combat Myocardial Fibrosis
(Georgetown University, 2021)
Stem cell research for treating or curing myocardial fibrosis has culminated in identifying which scenario is more important; 1) stem cell differentiation into cardiomyocytes that integrate electrically with the heart, 2) ...
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)
Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ...
Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)
Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ...
Organochlorines and Brain Homeostasis: Polychlorinated Biphenyls as Astrocytic Stressors
(Georgetown University, 2021)
Exposure to environmental toxicants is prevalent, hazardous and linked to varied detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of hazardous organochlorines once widely used for industrial ...
The Roles of RARRES1 and SIRT1/2 in B Cell Function and Homeostasis
(Georgetown University, 2021)
Upon cognate antigen encounter, naïve (antigen-inexperienced) B cells activate shifting from a state of quiescence to rapid clonal expansion and differentiation into germinal center (GC) B cells, antibody-secreting plasma ...
Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)
Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ...