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Somatostatin-GABA neurons regulate vago-vagal circuitry
(Georgetown University, 2016)
Parasympathetic regulation of the gastric antrum is mediated through the vago-vagal circuitry in which glutamatergic afferents relay peripheral information to the CNS and cholinergic efferents transmit the compensatory ...
ELECTRIC FIELDS AND SLOW CORTICAL ACTIVITY
(Georgetown University, 2013)
Electrical activity in the brain gives rise to endogenous electric fields, which are the cause of many signals recorded from the nervous system. Electric fields can also be applied from external sources to modulate the ...
The Effects of Inflammation on Dorsal Striatal Spiny Projection Neurons
(Georgetown University, 2017)
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of glutamate receptors. ...
Novel Roles for TRPA1 and TRPV1 in nutrient sensing and obesity
(Georgetown University, 2011)
In the first part of this thesis I explored a role for the capsaicin receptor TRPV1 in the regulation of feeding and body mass. On a diet containing 4.5% fat, wild-type and TRPV1-null mice gained equivalent body mass. On ...
Cholinergic Modulation of GABAergic Inhibition Dynamics In The Striatum
(Georgetown University, 2014)
The striatum contains medium spiny neurons (MSNs) classified by their axonal projection and expression of dopamine receptors into D1+ and D2+ MSNs; and interneurons including choline acetyltransferase expressing interneurons ...
MMP-1 Overexpression Selectively Alters Inhibition in D1 Spiny Projection Neurons in the Nucleus Accumbens and Disrupts Amphetamine Induced Locomotion
(Georgetown University, 2018)
Protease activated receptor-1 (PAR-1) and its ligand, matrix metalloproteinase-1 (MMP-1), are altered in several neurodegenerative diseases. PAR-1 and MMP-1 signaling impact neuronal excitation and inhibition in various ...