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Induction of apoptosis and autophagy by the small molecule inhibitor VMY-1-103 in cancer cell lines and reduction of tumor growth in vivo
(Georgetown University, 2013)
Cancer is a class of diseases in which cells divide uncontrollably and are able to spread throughout the body. In particular, cancer of the prostate and brain, specifically medulloblastoma, are particularly deadly because ...
Role of the Ubiquitin Proteasome System in the Regulation of V(D)J Recombination
(Georgetown University, 2012)
V(D)J recombination, the only known site specific DNA rearrangement in vertebrates, is the process that is responsible for the development of vertebrate adaptive immunity. It mediates the assembly of antigen receptor genes ...
The Contribution of PCPH to Colon Carcinoma
(Georgetown University, 2011)
PCPH is a well conserved, single-copy gene whose product is ubiquitously expressed but predominates in kidney, liver, and colon. The protein product belongs to the nucleoside triphosphate diphosphohydrolase family, NTPDase, ...
ALTERATION OF MAMMARY GLAND DEVELOPMENT AND GENE EXPRESSION BY IN UTERO EXPOSURE TO METALLOESTROGENS
(Georgetown University, 2012)
Early life exposure to estrogens and estrogen like contaminants in the environment are thought to increase the risk of developing breast cancer due to the early onset of puberty in the exposed female. However, the results ...
CIRCUMVENTING ANTIGEN LOSS TO POTENTIATE CANCER IMMUNOTHERAPY
(Georgetown University, 2015)
Cancer cells become resistant to monoclonal antibody (mAb) therapy when they lose the cell surface antigens that mAbs target. To circumvent immune escape and maximize the efficacy of mAb therapy, new approaches to mitigate ...
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)
This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ...
Interferon Regulatory Factor-1 (IRF1) Signaling Regulates Apoptosis and Autophagy to Determine Endocrine Responsiveness and Cell Fate in Human Breast Cancer
(Georgetown University, 2013)
Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor and pivotal regulator of cell fate in cancer cells. While IRF1 is known to possess tumor suppressive activities, the role of IRF1 in mediating apoptosis ...
"Examining TGF-beta Inhibition, via Smad7, and the Role of The Inhibitors of Differentiation (Id) in Metastatic Melanoma"
(Georgetown University, 2013)
TGF-β, Ids and tumorigenesis are interrelated. Smad7 (S7) has been shown to potently suppress melanomagenesis through downregulation of metastasis-related genes such as MMP2, MMP9, osteopontin and CXCR4. Here, we ...
A Systems Approach to Understand the Molecular Synergy of Combined mTOR/Histone Deacetylase (HDAC) Inhibition in the Treatment of Cancer
(Georgetown University, 2014)
The clinical necessity of combining molecularly targeted agents to effectively treat cancer is clear. At the molecular level, the limitations of single-target inhibition due to the complexity and redundancy of oncogenic ...
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)
Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ...