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Molecular Features of Human Bone Marrow Stem Cells
(Georgetown University, 2012)
Understanding the quality and quantity of resident bone marrow cells as well as circulating bone marrow derived cells (BMDC) are key to unlocking the complexity of their contribution to physiological hemostasis or pathological ...
The Radiosensitizing Potential of Rigosertib and Dinaciclib in Ewing's Sarcoma Cells
(Georgetown University, 2015)
Ewing’s sarcoma is the second most frequent bone cancer. However, it is still a relatively uncommon cancer, with only approximately 225 new cases diagnosed in patients under 20 years old each year in North America. Despite ...
THE CX3CR1+ LAMINA PROPRIA DENDRITIC CELL: MASTER SENTINEL OF THE TERMINAL ILEUM
(Georgetown University, 2012)
The CX3CR1+ lamina propria dendritic cell (LPDC) of the terminal ileum provides a unique sentinel role, critical for intestinal health. Here, we demonstrate that three Crohn's disease associated single nucleotide polymorphisms ...
ROLE OF BTG2 IN THE ANTIOXIDANT RESPONSE IN HUMAN BREAST EPITHELIAL CELLS.
(Georgetown University, 2012)
BTG2, a member of antiproliferative gene family BTG/TOB, has been implicated in cell cycle regulation, normal development and tumor suppression. However, the underlying mechanism(s) by which BTG2 regulates these processes ...
Neuronal DNA Double Strand Break Damage and Repair Following Sublethal iGluR Activation, and the Neuroprotective Effects of Melatonin
(Georgetown University, 2013)
DNA double strand break (DSB) damage is among the most lethal forms of DNA damage, and its repair in mature neurons remains largely unexamined, particularly following neuronal excitation. A major cause of DSBs is mediated ...
MECHANISMS OF OBESITY-RELATED HEPATOCARCINOGENSIS
(Georgetown University, 2017)
Nearly a third of the US population is currently obese. The recent rise in liver cancer prevalence correlates with the obesity epidemic and non-alcoholic fatty liver disease (NAFLD). The underlying mechanisms behind the ...
Regulators of Cancer Cell Vascular Invasion and Malignancy
(Georgetown University, 2018)
A metastasizing cancer cell will experience a series of diverse and often lethal selective pressures as it travels from a primary tumor to a distant organ site. Two crucial events in this multistep journey encompass cancer ...
The Role of T Cells in the Hypertension of the Female Dahl Salt-Sensitive Rat
(Georgetown University, 2018)
Hypertension (HT) is a major risk factor for cardiovascular diseases (CVD) and affects 1 billion men and women globally. The underlying cause of HT in women is far less studied than in men. Hence it is critically important ...
The Application of Conditional Reprogramming to Drug Discovery and Regenerative Medicine
(Georgetown University, 2018)
The Conditional Reprogramming (CR) method has been shown to induce an in vitro stem-like state allowing for the continuous growth of patient-derived epithelial cells. Due to this new culture system, it has been possible ...
RARRES1 Modulation of Tubulin Deglutamylation Regulates Metabolism and Cell Survival
(Georgetown University, 2018)
One of the driving mechanisms of cancer progression is the reprogramming of metabolic pathways in intermediary metabolism. Cancers increase their energy expenditure by increasing ATP production for utilization in anabolic ...