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Novel Base Excision Repair and Hypoxanthine in Live Human Cells
(Georgetown University, 2018)
Elucidating the mechanism of DNA damage and mutation is key to understating cancer genesis. In the first section of this thesis we examined base excision repair enzymes (BER) responsible for mitigating damage to DNA. BER ...
Elucidating the Role of Plasticity-Related Gene Type 3 Protein in the Central Nervous System
(Georgetown University, 2018)
PRG-3 (Plasticity-Related Gene), a member of a family of lipid phosphatase related proteins, also known as Phospholipid Phosphatase-Related Protein Type (PLPPR) proteins, are integral membrane proteins characterized by six ...
Distinct Roles for EphA7 Isoforms in Cortical Dendritic Elaboration and Synapse Formation
(Georgetown University, 2017)
The cerebral cortex consists of complex circuitry that directs diverse functions. Development of the cortex relies upon precise coordination between inherent genetic programs and environmental signals to create distinct ...
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)
Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ...
Expression Levels of the Nuclear Coactivator AIB1 in Drug Resistance and Tumor Progression of Triple Negative Breast Cancer
(Georgetown University, 2019)
Breast cancer is the most diagnosed cancer and the most frequent cause of cancer mortality in women worldwide. Immunoreactive assays as well as gene expression profiling of breast cancer have shown a high degree of ...
Novel Relationships of Splicing Factors and Regulation in TMZ-Resistant Glioblastoma
(Georgetown University, 2019)
Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ...
Enhancing Anti-Cancer Properties of Human Natural Killer Cells
(Georgetown University, 2021)
Immunotherapy has revolutionized cancer treatment. Certain immunotherapies, such as immune checkpoint inhibitors and CAR-T cell therapy, provide long lasting remissions. Unfortunately, the majority of tumors are unresponsive ...
Targeting WEE1 in Standard Therapy Resistant Estrogen Receptor Positive Breast Cancer
(Georgetown University, 2021)
Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors that progress on antiestrogens are ...
Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (CICS) Derived from Germline Pluripotent Stem Cells (HGPSCS) to Combat Myocardial Fibrosis
(Georgetown University, 2021)
Stem cell research for treating or curing myocardial fibrosis has culminated in identifying which scenario is more important; 1) stem cell differentiation into cardiomyocytes that integrate electrically with the heart, 2) ...
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)
Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ...