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Hippocampal Microcircuit Alterations in Early Amyloid Pathology: A Selective Impairment of Parvalbumin-Expressing Basket Cells During Sharp Wave Ripple Events
(Georgetown University, 2020)
Memory disruption in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, particularly at early stages preceding neurodegeneration. In mouse models of AD, there are disruptions to sharp wave ...
Solute Carriers and Heat Shock Proteins Modulate Endocrine Therapy Resistance in Hormone Positive Breast Cancer
(Georgetown University, 2020)
Resistance to endocrine therapies remains a major challenge for patients with estrogen receptor-positive (ER+) breast cancer. Adaptive reprogramming of cellular metabolism in response to treatment is one feature of this ...
The Role of T-LAK Cell-Originated Protein Kinase (TOPK) in Modulating Prostate Cancer Stemness and Androgen Independence
(Georgetown University, 2020)
The predominant clinical challenge in the treatment of prostate cancer (CaP) is how to differentiate aggressive CaP from indolent ones. Previously, our lab has demonstrated that a protein kinase, T-LAK cell-originated ...