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ERRβ Splice Variants Differentially Regulate Cell Cycle Progression
(Georgetown University, 2014)
Orphan receptors comprise nearly half of all members of the nuclear receptor superfamily. Despite having broad structural similarities to the classical estrogen receptors, estrogen-related receptors (ERRs) have their own ...
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)
An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ...
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)
This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ...
A Systems Approach to Understand the Molecular Synergy of Combined mTOR/Histone Deacetylase (HDAC) Inhibition in the Treatment of Cancer
(Georgetown University, 2014)
The clinical necessity of combining molecularly targeted agents to effectively treat cancer is clear. At the molecular level, the limitations of single-target inhibition due to the complexity and redundancy of oncogenic ...