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Regulators of Cancer Cell Vascular Invasion and Malignancy
(Georgetown University, 2018)
A metastasizing cancer cell will experience a series of diverse and often lethal selective pressures as it travels from a primary tumor to a distant organ site. Two crucial events in this multistep journey encompass cancer ...
The Role of T Cells in the Hypertension of the Female Dahl Salt-Sensitive Rat
(Georgetown University, 2018)
Hypertension (HT) is a major risk factor for cardiovascular diseases (CVD) and affects 1 billion men and women globally. The underlying cause of HT in women is far less studied than in men. Hence it is critically important ...
The Application of Conditional Reprogramming to Drug Discovery and Regenerative Medicine
(Georgetown University, 2018)
The Conditional Reprogramming (CR) method has been shown to induce an in vitro stem-like state allowing for the continuous growth of patient-derived epithelial cells. Due to this new culture system, it has been possible ...
RARRES1 Modulation of Tubulin Deglutamylation Regulates Metabolism and Cell Survival
(Georgetown University, 2018)
One of the driving mechanisms of cancer progression is the reprogramming of metabolic pathways in intermediary metabolism. Cancers increase their energy expenditure by increasing ATP production for utilization in anabolic ...
Novel Base Excision Repair and Hypoxanthine in Live Human Cells
(Georgetown University, 2018)
Elucidating the mechanism of DNA damage and mutation is key to understating cancer genesis. In the first section of this thesis we examined base excision repair enzymes (BER) responsible for mitigating damage to DNA. BER ...
Elucidating the Role of Plasticity-Related Gene Type 3 Protein in the Central Nervous System
(Georgetown University, 2018)
PRG-3 (Plasticity-Related Gene), a member of a family of lipid phosphatase related proteins, also known as Phospholipid Phosphatase-Related Protein Type (PLPPR) proteins, are integral membrane proteins characterized by six ...