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ERRβ Splice Variants Differentially Regulate Cell Cycle Progression
(Georgetown University, 2014)
Orphan receptors comprise nearly half of all members of the nuclear receptor superfamily. Despite having broad structural similarities to the classical estrogen receptors, estrogen-related receptors (ERRs) have their own ...
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)
An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ...
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)
Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ...
Drivers of cancer cell invasion and metastasis
(Georgetown University, 2012)
Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, extravasation at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and ...
Induction of apoptosis and autophagy by the small molecule inhibitor VMY-1-103 in cancer cell lines and reduction of tumor growth in vivo
(Georgetown University, 2013)
Cancer is a class of diseases in which cells divide uncontrollably and are able to spread throughout the body. In particular, cancer of the prostate and brain, specifically medulloblastoma, are particularly deadly because ...
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)
This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ...
"Examining TGF-beta Inhibition, via Smad7, and the Role of The Inhibitors of Differentiation (Id) in Metastatic Melanoma"
(Georgetown University, 2013)
TGF-β, Ids and tumorigenesis are interrelated. Smad7 (S7) has been shown to potently suppress melanomagenesis through downregulation of metastasis-related genes such as MMP2, MMP9, osteopontin and CXCR4. Here, we ...
Pleiotrophin (PTN) Growth Factor Function in Epithelial Cells During Mouse Mammary Gland Development
(Georgetown University, 2011)
Mammary gland development is a complex process requiring numerous systemic hormones as well as local regulatory factors. Expression of the heparin-binding growth factor, pleiotrophin (PTN) in the mouse mammary gland and ...
Molecular Features of Human Bone Marrow Stem Cells
(Georgetown University, 2012)
Understanding the quality and quantity of resident bone marrow cells as well as circulating bone marrow derived cells (BMDC) are key to unlocking the complexity of their contribution to physiological hemostasis or pathological ...
The Radiosensitizing Potential of Rigosertib and Dinaciclib in Ewing's Sarcoma Cells
(Georgetown University, 2015)
Ewing’s sarcoma is the second most frequent bone cancer. However, it is still a relatively uncommon cancer, with only approximately 225 new cases diagnosed in patients under 20 years old each year in North America. Despite ...