Lombardi Comprehensive Cancer Center
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The Molecular Mechanisms Underlying the Pathophysiological Role of Membrane-Bound Proteolysis in Human Skin
(Georgetown University, 2023)Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease inhibitor HAI-1 represents the primary enzymatic inhibitor for both ... -
Epigenetic Regulation in Cancers: PRMT1-Driven Development of Gemcitabine Resistance through Modulation of MAFF/BACH1 Chromatin Dynamics in Pancreatic Ductal Adenocarcinoma (PDAC)
(Georgetown University, 2023)Pancreatic Ductal Adenocarcinoma (PDAC) is associated with severe prognosis due to late diagnosis and therapeutic resistance. Here we show that PDAC cells undergo progressive reprogramming of the global epigenetic landscape ... -
Effects of CDK4/6 Inhibitor-Induced Stromal Senescence on the Metastatic Niche and Metastasis of Breast Cancer
(Georgetown University, 2023)CDK4/6 inhibitors (CDKI) have improved disease control in hormone receptor-positive, HER2-negative metastatic breast cancer, but most patients still develop progressive disease. It is unclear to what extent host responses ... -
The Integration of TGFβ and Egfr Signaling Programs Confers the Ability to Lead Heterogeneous Collective Invasion
(Georgetown University, 2023)Tumors comprise of cells that can adapt and evolve overtime to perform different functions including invasion, metastasis, therapy resistance and immune evasion. These phenotypic states are distributed across distinct ... -
The Role of Cadmium in the Activation of the Estrogen Receptor Alpha and Endocrine Resistance
(Georgetown University, 2022)The estrogen receptor alpha (ER) plays a central role in the etiology, progression, and treatment of hormone dependent breast cancers. Constitutively activating somatic mutations in the ESR1 (estrogen receptor alpha (ER)) ...
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