Browsing Lombardi Comprehensive Cancer Center by Title
Now showing items 1-20 of 104
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Addressing Thoracic Cancers: Biomarker and Pre-Clinical Drug Discovery in Non-Small Cell Lung Cancer and Thymic Carcinoma
(Georgetown University, 2020)Thoracic cancer is a term that encompasses numerous malignancies within the thoracic cavity; the term includes malignancies such as lung cancers and thymic epithelial tumors. Lung cancers are the leading cause of cancer ... -
AIB1 and ANCO1 Regulate YAP/TEAD Signaling in Early Stage Basal Breast Cancer
(Georgetown University, 2019)The progression of ductal carcinoma in-situ (DCIS) to locally invasive breast cancer precedes distant metastases and disease lethality. The Amplified In Breast cancer 1 (AIB1) transcription coactivator becomes overexpressed ... -
Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to its HLA-C Ligand
(Georgetown University, 2013)Although extensive homology exists between their extracellular domains, natural killer cell inhibitory receptors KIR2DL2*001 and KIR2DL3*001 have previously been shown to differ substantially in their HLA-C binding avidity. ... -
An Assessment of Common Approaches to Estimating Peak Skin Dose Rresulting from Fluoroscopically Guided Interventions
(Georgetown University, 2017)Fluoroscopy guided procedures are increasing in complexity, and with that, Peak Skin Doses (PSD) that produce cutaneous radiation injury are a growing concern. Direct measurement of PSD is possible, but the decision to do ... -
Antibody Depdendent Cell-Mediated Cytotoxicity (ADCC) Selection Pressure Induces Diverse and Reversible Mechanisms of Resistance
(Georgetown University, 2022)Targeted monoclonal antibody therapy has emerged as a powerful therapeutic strategy for cancer. Unfortunately, only a minority of patients have durable responses and the development of resistance remains a major clinical ... -
Assessing Leakage Workloads of Medical Linear Accelerators for IMRT and TBI Techniques
(2007-12-10)Current estimates for leakage workloads are not well quantified for Intensity Modulated Radiation Therapy (IMRT) and Total Body Irradiation (TBI) treatments. When analyzed on a large scale, using a large sample, a well ... -
BCL-2 family function in antiestrogen-resistant breast cancer cells
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Beta Radiation Response of SIRAD® Colorimetric Dosimeter vs. Theoretical Calculation of Beta Dose in the 5 to 25 rad Range
(Georgetown University, 2012)<bold>ABSTRACT -
BRCA1-mimetic Compound NSC35446.HCl Inhibits IKKB Expression by Reducing Estrogen Receptor-α Occupancy in the IKKB Promoter and Inhibits NF-κB Activity in Antiestrogen-resistant Human Breast Cancer Cells
(Georgetown University, 2017)BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor--α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells -
CADHERIN-11 MEDIATION OF TUMOR PROGRESSION AND INVASION IN POOR PROGNOSIS CANCERS: A VIABLE THERAPEUTIC TARGET
(Georgetown University, 2009)Loss of E-cadherin is considered a hallmark of epithelial carcinogenesis and has been well-studied to date. Likewise, increases in N-cadherin are known to lead to tumor progression and metastasis in various cancers. A ... -
Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ... -
CDK inhibitor VMY-1-103 causes cell cycle arrest and apoptosis in cancer cell lines
(Georgetown University, 2012)The mammalian cell cycle is a tightly controlled process that -
Characterization of a Commercial Optically Stimulated Luminescence Dosimetry System
(Georgetown University, 2017)There is a need to better understand the risks of low level radiation dose in medical diagnostic procedures and ensure that dose measurements are accurate and traceable to National Standards. Users of instruments typically ... -
Characterizing Dose Rate Variability of a Mark I Cesium-137 Irradiator
(Georgetown University, 2015)The Mark I irradiator is commonly used by institutions of higher learning and other facilities to administer a given radiation dose to numerous materials. Growing concern regarding highly variable mouse survival data ... -
CIRCUMVENTING ANTIGEN LOSS TO POTENTIATE CANCER IMMUNOTHERAPY
(Georgetown University, 2015)Cancer cells become resistant to monoclonal antibody (mAb) therapy when they lose the cell surface antigens that mAbs target. To circumvent immune escape and maximize the efficacy of mAb therapy, new approaches to mitigate ... -
Common Table Salt Used as a Retrospective Dosimeter Using Thermoluminescence
(Georgetown University, 2019)In this study, the feasibility of using common table salt as a retrospective dosimeter was evaluated using thermoluminescence. In an event of a terrorist act in which radioactive material is used in a dispersal device, ... -
DAP12 impacts trafficking and surface stability of killer cell immunoglobulin-like receptors on natural killer cells
(Georgetown University, 2012)Killer cell immunoglobulin-like receptors (KIR) aid in the regulation of natural killer (NK) cell activity. In this study, the effect of the interaction between the two domain stimulatory KIR (KIR2DS) and their adapter, ... -
Defining the Factors that Regulate the Conversion to a Trailblazer Epithelial to Mesenchymal Transition State
(Georgetown University, 2021)Tumor heterogeneity resulting from the co-existence of phenotypically diverse tumor cellpopulations is a major contributor in the pathogenesis of several human malignancies. In addition to the steady acquisition of heritable ... -
DEREGULATED ESTROGEN RECEPTOR ALPHA-INITIATED PRENEOPLASIA AND ITS PROGRESSION: ROLE OF STAT5A AND CYCLIN D1
(Georgetown University, 2009)Deregulation of estrogen pathway has been linked to the pathophysiology of breast cancer. CERM (Conditional Estrogen Receptor alpha in Mammary epithelium) mice with deregulated ERalpha (ER) in the mammary epithelium develop ... -
Determining the Isotopic Concentration of Uranium from Vector Representation of the Gamma Spectrum
(Georgetown University, 2014)DETERMINING THE ISOTOPIC CONCENTRATION OF URANIUM FROM VECTOR REPRESENTATION OF THE GAMMA SPECTRUM
