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Expression Levels of the Nuclear Coactivator AIB1 in Drug Resistance and Tumor Progression of Triple Negative Breast Cancer
(Georgetown University, 2019)
Breast cancer is the most diagnosed cancer and the most frequent cause of cancer mortality in women worldwide. Immunoreactive assays as well as gene expression profiling of breast cancer have shown a high degree of ...
Novel Relationships of Splicing Factors and Regulation in TMZ-Resistant Glioblastoma
(Georgetown University, 2019)
Glioblastoma (GBM) is a devastating cancer, due to both our narrow understanding of its molecular drivers and limited therapeutic strategies. The blood-brain barrier (BBB) limits the chemotherapeutic options for the treatment ...
T Cell Based Immunotherapy Targeting Fibroblast Growth Factor Receptor 4 as a Therapeutic against Rhabdomyosarcoma
(Georgetown University, 2019)
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, has a low mutational burden with few actionable somatic targets. Fibroblast growth factor receptor 4 (FGFR4) is a candidate therapeutic target in ...
Effects of CDK4/6 Inhibition on Progression of Early Stage Breast Cancer
(Georgetown University, 2019)
Here we demonstrate the efficacy of palbociclib in targeting the cell cycle kinase CDK4/6 and canonical pathways downstream in both normal breast epithelial (MCF10A) and early stage breast cancer cells (MCFDCIS) resulting ...