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The Response of Cancer Cells to Local Changes in Extracellular Stiffness
(Georgetown University, 2017)
Durotaxis is a mechanism of directed cell migration in which cells respond to gradients of extracellular stiffness. While durotaxis has been predominantly characterized in a subset of mesenchymal cells, the potential for ...
ERRβ Splice Variants Differentially Regulate Cell Cycle Progression
(Georgetown University, 2014)
Orphan receptors comprise nearly half of all members of the nuclear receptor superfamily. Despite having broad structural similarities to the classical estrogen receptors, estrogen-related receptors (ERRs) have their own ...
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer
(Georgetown University, 2014)
An early detection and monitoring of pancreatic adenocarcinoma has been very challenging, which makes it one of the deadliest cancers today. This has stimulated research to explore new therapeutic strategies and new ways ...
The Molecular Determinants of Tumor Cell Sensitivity and Resistance to Antibody-Dependent Cellular Cytotoxicity (ADCC)
(Georgetown University, 2013)
Monoclonal antibodies represent the vanguard of targeted therapy due to their specificity and versatility. Aside from disrupting tumor cell survival and proliferation through cell surface receptor interactions, antibodies ...
THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS
(Georgetown University, 2012)
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal ...
THE MECHANISMS OF REVERSAL OF REFRACTORY DYSPLASIA IN THE SALIVARY GLAND: TESTING THE ROLE OF P53, RXR AND PPARGAMMA AGONISTS, AND PD0332991
(Georgetown University, 2012)
Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both ...
Drivers of cancer cell invasion and metastasis
(Georgetown University, 2012)
Metastatic spread of cancer cells from their primary site requires invasion into the vasculature, extravasation at the distant organ site and colonization of the distant organ. Here we studied mechanisms of attachment and ...
Induction of apoptosis and autophagy by the small molecule inhibitor VMY-1-103 in cancer cell lines and reduction of tumor growth in vivo
(Georgetown University, 2013)
Cancer is a class of diseases in which cells divide uncontrollably and are able to spread throughout the body. In particular, cancer of the prostate and brain, specifically medulloblastoma, are particularly deadly because ...
CIRCUMVENTING ANTIGEN LOSS TO POTENTIATE CANCER IMMUNOTHERAPY
(Georgetown University, 2015)
Cancer cells become resistant to monoclonal antibody (mAb) therapy when they lose the cell surface antigens that mAbs target. To circumvent immune escape and maximize the efficacy of mAb therapy, new approaches to mitigate ...
Regulation of MicroRNAs Targeting the Angiogenic Switch Molecule Fibroblast Growth Factor Binding Protein 1 by Retinoic Acid Receptor Activation
(Georgetown University, 2014)
This dissertation examines the role of retinoic acid receptor activation in the post-transcriptional regulation of a fibroblast growth factor binding protein. Previous work showed that all-trans retinoic acid (ATRA) reduces ...