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Cassette Exon RNA Splicing Altered in Ewing Sarcoma Is Characterized by Higher Guanine-Cytosine Content and Lower Splice Site Strength Indicative of Intron-Definition Splicing
(Georgetown University, 2021)
Ewing sarcoma (EwS) is a pediatric cancer that typically presents at a mean of 15 years of age and is the second most common bone tumor in children and adolescents. While there have been substantial investigations into the ...
The Roles of RARRES1 and SIRT1/2 in B Cell Function and Homeostasis
(Georgetown University, 2021)
Upon cognate antigen encounter, naïve (antigen-inexperienced) B cells activate shifting from a state of quiescence to rapid clonal expansion and differentiation into germinal center (GC) B cells, antibody-secreting plasma ...
T Cell Based Immunotherapy Targeting Fibroblast Growth Factor Receptor 4 as a Therapeutic against Rhabdomyosarcoma
(Georgetown University, 2019)
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, has a low mutational burden with few actionable somatic targets. Fibroblast growth factor receptor 4 (FGFR4) is a candidate therapeutic target in ...
Effects of CDK4/6 Inhibition on Progression of Early Stage Breast Cancer
(Georgetown University, 2019)
Here we demonstrate the efficacy of palbociclib in targeting the cell cycle kinase CDK4/6 and canonical pathways downstream in both normal breast epithelial (MCF10A) and early stage breast cancer cells (MCFDCIS) resulting ...
Solute Carriers and Heat Shock Proteins Modulate Endocrine Therapy Resistance in Hormone Positive Breast Cancer
(Georgetown University, 2020)
Resistance to endocrine therapies remains a major challenge for patients with estrogen receptor-positive (ER+) breast cancer. Adaptive reprogramming of cellular metabolism in response to treatment is one feature of this ...