Collections in this community

Browse All Items

Most Recent Submissions

  • TCR Activation Impact On Chimeric Antigen Receptor Therapy Against Acute Lymphoblastic Leukemia 

    Yang, Yinmeng (Georgetown University, 2016)
    Tremendous progress has been achieved employing immunotherapy for B cell acute lymphoblastic leukemia (ALL), the most common diagnosis in children with cancer and a leading cause of cancer-related death. Recent trials using ...
  • Timing of dietary exposures and tamoxifen resistance in rats 

    Zhang, Xiyuan (Georgetown University, 2016)
    In the USA, one in eight women develop invasive breast cancer at some point of her life, and 70% of the cancers are estrogen receptor positive and thus are treated with antiestrogen therapy. However, half of the treated ...
  • ETS FAMILY OF TRANSCRIPTION FACTORS AS A THERAPEUTIC TARGET IN CANCER 

    Minas, Tsion Zewdu (Georgetown University, 2016)
    The ETS family of transcription factors share a conserved DNA binding domain that recognizes a purine rich consensus sequence with GGAA/T motif. ETS genes have been implicated in a wide array of malignancies including acute ...
  • TISSUE SPECIFIC PEPTIDE CONJUGATES FOR DRUG DELIVERY 

    Cordova, Antoinette (Georgetown University, 2015)
    Cytotoxic agents and targeted small molecules are used to treat cancer and disease, but are limited by systemic toxicity. The key to addressing this important issue is the development of a non-toxic, selective and specific ...
  • The Molecular Determinants of Tumor Cell Modulation of Immune Selection 

    Shuptrine, Casey Weber (Georgetown University, 2015)
    Over the past century, the identification of molecules that tumor cells utilize to manipulate the activation or survival of immune cells has proven difficult. Expression analyses have helped to discover the downregulation ...

View more