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"Examining TGF-beta Inhibition, via Smad7, and the Role of The Inhibitors of Differentiation (Id) in Metastatic Melanoma"
(Georgetown University, 2013)
TGF-β, Ids and tumorigenesis are interrelated. Smad7 (S7) has been shown to potently suppress melanomagenesis through downregulation of metastasis-related genes such as MMP2, MMP9, osteopontin and CXCR4. Here, we ...
Investigation of Potential Targets of Chemotherapy in Ewing Sarcoma and Prostate Cancer
(Georgetown University, 2020)
Cancer-specific features are attractive targets for novel chemotherapies. In Ewing sarcoma, two characteristic features are the cell-surface protein CD99 and the EWS-FLI1 fusion protein. CD99 expression in Ewing sarcoma ...
Identifying and Evaluating Mechanisms of Drug Resistance in Cancer
(Georgetown University, 2019)
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. We have utilized a patient-derived bladder cancer xenograft (PDX) platform to characterize ...