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α-SYNUCLEIN DISRUPTS INTEGRATED SIGNALING BY THE UNFOLDED PROTEIN RESPONSE THROUGH INHIBITION OF ATF6-α INCORPORATION INTO COPII VESICLES
(Georgetown University, 2015)
Parkinson's Disease (PD) is a neurodegenerative disease characterized by the advanced loss of motor functions as a result of progressive degenerative conditions that develop in many regions of the brain and manifest as a ...
EFFECTS OF TNFAIP8 KNOCKDOWN ON EGFR AND IGF-1R SIGNALING AND CYTOTOXICITIES OF TARGETED DRUGS IN NON-SMALL CELL LUNG CANCER CELLS
(Georgetown University, 2015)
Lung cancer is the most commonly diagnosed cancer and leading cause of cancer-related deaths worldwide. Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancer cases. Molecular therapies targeting epidermal ...
Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
Role of the Ubiquitin Proteasome System in the Regulation of V(D)J Recombination
(Georgetown University, 2012)
V(D)J recombination, the only known site specific DNA rearrangement in vertebrates, is the process that is responsible for the development of vertebrate adaptive immunity. It mediates the assembly of antigen receptor genes ...
The Contribution of PCPH to Colon Carcinoma
(Georgetown University, 2011)
PCPH is a well conserved, single-copy gene whose product is ubiquitously expressed but predominates in kidney, liver, and colon. The protein product belongs to the nucleoside triphosphate diphosphohydrolase family, NTPDase, ...
ALTERATION OF MAMMARY GLAND DEVELOPMENT AND GENE EXPRESSION BY IN UTERO EXPOSURE TO METALLOESTROGENS
(Georgetown University, 2012)
Early life exposure to estrogens and estrogen like contaminants in the environment are thought to increase the risk of developing breast cancer due to the early onset of puberty in the exposed female. However, the results ...
"Examining TGF-beta Inhibition, via Smad7, and the Role of The Inhibitors of Differentiation (Id) in Metastatic Melanoma"
(Georgetown University, 2013)
TGF-β, Ids and tumorigenesis are interrelated. Smad7 (S7) has been shown to potently suppress melanomagenesis through downregulation of metastasis-related genes such as MMP2, MMP9, osteopontin and CXCR4. Here, we ...
THE CX3CR1+ LAMINA PROPRIA DENDRITIC CELL: MASTER SENTINEL OF THE TERMINAL ILEUM
(Georgetown University, 2012)
The CX3CR1+ lamina propria dendritic cell (LPDC) of the terminal ileum provides a unique sentinel role, critical for intestinal health. Here, we demonstrate that three Crohn's disease associated single nucleotide polymorphisms ...
ROLE OF BTG2 IN THE ANTIOXIDANT RESPONSE IN HUMAN BREAST EPITHELIAL CELLS.
(Georgetown University, 2012)
BTG2, a member of antiproliferative gene family BTG/TOB, has been implicated in cell cycle regulation, normal development and tumor suppression. However, the underlying mechanism(s) by which BTG2 regulates these processes ...
MECHANISMS OF OBESITY-RELATED HEPATOCARCINOGENSIS
(Georgetown University, 2017)
Nearly a third of the US population is currently obese. The recent rise in liver cancer prevalence correlates with the obesity epidemic and non-alcoholic fatty liver disease (NAFLD). The underlying mechanisms behind the ...